Table 2.
Change in FEV1, Exacerbations and HRQoL for 3016 Patients Who Completed Both Questionnaires
| Baseline | 1-Year | 1-Year Change | 1-Year % Change | p-value | ||
|---|---|---|---|---|---|---|
| FEV1 (Liter) | Total sample | 1.88 (±0.75) | 1.85 (±0.73) | −0.03 | −1.7% | 0.0005 |
| A | 2.09 (±0.73) | 2.01 (±0.69) | −0.08 | −3.7% | <0.0001 | |
| B | 1.73 (±0.68) | 1.72 (±0.69) | −0.01 | −0.7% | 0.4209 | |
| C | 2.01 (±0.79) | 1.97 (±0.76) | −0.04 | −2.2% | 0.1149 | |
| D | 1.51 (±0.76) | 1.58 (±0.8) | 0.07 | 4.7% | 0.0268 | |
| Moderate exacerbations | Total sample | 0.84 (±1.93) | 0.95 (±2.07) | 0.11 | 13.0% | <0.0001 |
| A | 0.08 (±0.27) | 0.21 (±0.74) | 0.13 | 154.7% | <0.0001 | |
| B | 0.08 (±0.27) | 0.29 (±0.9) | 0.22 | 278.2% | <0.0001 | |
| C | 4.23 (±2.43) | 3.83 (±2.86) | −0.40 | −9.4% | 0.0099 | |
| D | 3.72 (±2.69) | 3.76 (±3.07) | 0.03 | 0.9% | 0.7503 | |
| Severe exacerbations | Total sample | 0.07 (±0.39) | 0.1 (±0.46) | 0.03 | 35.7% | 0.0010 |
| A | 0 (±0) | 0.03 (±0.2) | 0.03 | / | <0.0001 | |
| B | 0 (±0) | 0.08 (±0.36) | 0.08 | / | <0.0001 | |
| C | 0.2 (±0.64) | 0.15 (±0.62) | −0.05 | −26.7% | 0.1803 | |
| D | 0.47 (±0.88) | 0.37 (±0.92) | −0.10 | −21.2% | 0.0302 | |
| HRQoL: VAS | Total sample | 58.59 (±19.94) | 57.51 (±20.59) | −1.08 | −1.8% | 0.0006 |
| A | 68.2 (±17.23) | 66.94 (±17.94) | −1.25 | −1.8% | 0.0050 | |
| B | 50.24 (±17.54) | 49.52 (±18.58) | −0.72 | −1.4% | 0.1802 | |
| C | 65.22 (±18.46) | 63.9 (±19.11) | −1.32 | −2.0% | 0.2714 | |
| D | 46.37 (±18.66) | 44.92 (±19.24) | −1.45 | −3.1% | 0.1388 | |
| HRQoL: CAT | Total sample | 19.2 (±7.7) | 19.75 (±7.9) | 0.54 | 2.8% | <0.0001 |
| A | 15.1 (±6.19) | 15.93 (±6.86) | 0.84 | 5.5% | <0.0001 | |
| B | 22.75 (±6.8) | 22.99 (±7.1) | 0.23 | 1.0% | 0.1903 | |
| C | 15.88 (±7.03) | 17.16 (±6.86) | 1.28 | 8.1% | 0.0008 | |
| D | 24.77 (±6.58) | 24.78 (±7.03) | 0.01 | 0.1% | 0.9654 | |
Note: Data are presented as mean (± SD) at baseline and follow-up.
Abbreviations: FEV1, forced expiratory volume in 1 second; HRQoL, health-related quality of life; VAS, visual analog scale; CAT, COPD Assessment Test.