Table 1.
List of all the proteins in the final SigPath assay panel
| HUGO‐approved symbol | Number of phosphosites | HUGO‐approved symbol | Number of phosphosites | HUGO‐approved symbol | Number of phosphosites | HUGO‐approved symbol | Number of phosphosites |
|---|---|---|---|---|---|---|---|
| ABI1 | 1 | FGFR1 | 1 | MAPRE1 | 1 | RBM39 | 1 |
| ABL1 | 1 | FGFR2 | 1 | MARCKS | 2 | RBM7 | 1 |
| ACIN1 | 1 | FGFR3 | 3 | MARVELD2 | 1 | RELA | 1 |
| AKT1 | 2 | FGFR4 | 1 | MAST2 | 1 | RET | 1 |
| AKT1S1 | 1 | FLT3 | 1 | MCL1 | 2 | RICTOR | 2 |
| AKT2 | 1 | FOXO1 | 2 | MDM2 | 1 | RIPK1 | 2 |
| AKT3 | 1 | FOXO3 | 2 | MET | 1 | ROS1 | 1 |
| ALK | 3 | FRS2 | 3 | MITF | 1 | RPS27 | 1 |
| ANLN | 1 | FRS3 | 1 | MOB1A | 1 | RPS6 | 3 |
| APLP2 | 1 | GAB1 | 1 | MPZL1 | 1 | RPS6KA1 | 4 |
| ARAF | 4 | GLYR1 | 1 | MTOR | 3 | RPS6KA2 | 1 |
| ATM | 1 | GRB2 | 1 | MYC | 1 | RPS6KA3 | 3 |
| AURKA | 1 | GSK3A | 1 | MYCBP2 | 1 | RPS6KB1 | 2 |
| AURKB | 1 | GSK3B | 2 | NF2 | 1 | RREB1 | 1 |
| AXL | 1 | GTF2I | 1 | NFKB1 | 1 | SHB | 1 |
| Bad | 2 | HECTD1 | 1 | NFKB1 | 1 | SHC1 | 2 |
| BCL2 | 1 | HGS | 1 | NFKBIA | 3 | SMAP | 1 |
| BCL2L11 | 1 | HIF1A | 2 | NTRK1 | 1 | SMARCA4 | 1 |
| BRAF | 2 | HMGN1 | 1 | NTRK2 | 1 | SMC4 | 1 |
| BRCA1 | 1 | HNRNPA3 | 1 | NUCKS1 | 1 | SOCS3 | 1 |
| BTK | 2 | HSPBL2 | 1 | PAK1 | 1 | SOS1 | 2 |
| BUB1 | 1 | IGF1R | 2 | PALLD | 1 | SPRY1 | 1 |
| CAMSAP2 | 1 | INSR | 1 | PBRM1 | 1 | SPRY2 | 3 |
| CDC20 | 1 | IRF3 | 1 | PDPK1 | 1 | SPRY4 | 1 |
| CDK1 | 2 | IRS1 | 2 | PEA15 | 1 | SRC | 1 |
| CFAP97 | 1 | IRS2 | 3 | PGAM1 | 1 | STAT3 | 2 |
| Chek1 | 2 | JAK1 | 1 | PHIP | 1 | STAT5A | 1 |
| CIC | 1 | JAK2 | 1 | PIK3R1 | 3 | STK3 | 1 |
| CPSF6 | 1 | JUN | 1 | PLCB3 | 1 | STK39 | 1 |
| CRK | 1 | JUND | 1 | PLCG1 | 1 | STK4 | 2 |
| CTNNB1 | 2 | KIF2C | 1 | PLCG2 | 1 | STMN1 | 1 |
| DDI2 | 1 | KIF4A | 1 | PLK1 | 2 | SUFU | 1 |
| DNAH5 | 1 | KIT | 1 | PPP2R5B | 1 | SYK | 1 |
| DOCK5 | 1 | KMT2A | 1 | PRKAA1 | 1 | SYNPO2 | 1 |
| DOT1L | 1 | KSR1 | 2 | PRKACA | 1 | TAZ | 1 |
| DYRK2 | 1 | LAG3 | 1 | PRKCA | 1 | TP53 | 2 |
| EGFR | 4 | LATS1 | 2 | PRKCB | 2 | TP53BP1 | 1 |
| EIF2A | 2 | LATS1 | 2 | PRKCB | 1 | TPX2 | 1 |
| EIF2AK4 | 1 | LATS2 | 1 | PRKCD | 1 | TSC2 | 1 |
| EIF4EBP1 | 3 | LCK | 1 | PRKCQ | 1 | TTC39B | 1 |
| EML4 | 1 | LYN | 1 | PRKCZ | 1 | UBE2J1 | 1 |
| EPAS1 | 1 | MAP2K1 | 2 | PRKD2 | 1 | ULK1 | 1 |
| EPHA2 | 1 | MAP2K4 | 1 | PRKDC | 1 | VAV1 | 1 |
| EPS8 | 1 | MAP3K14 | 2 | PTEN | 1 | VEPH1 | 1 |
| ERBB2 | 2 | MAP3K7 | 1 | PTK2 | 3 | VIM | 1 |
| ERBB3 | 2 | MAPK1 | 2 | PTPN11 | 4 | XIAP | 1 |
| ERBB4 | 1 | MAPK14 | 2 | RAB11B | 1 | YAP1 | 2 |
| ERH | 1 | MAPK3 | 2 | RAF1 | 9 | YTHDC1 | 1 |
| ERRFI | 1 | MAPK8 | 2 | RAF1 | 1 | ZAP70 | 1 |
| EZH2 | 2 | MAPK9 | 1 | RB1 | 3 | ZNF638 | 1 |
Table includes HUGO gene names and number of phosphosites per protein in the assay panel.