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Senescence-associated changes in m6A and m5C modifications. The main modifications reported in mRNAs encoding senescence-associated proteins, m6A and m5C, are indicated (gray rectangles). Each modification can promote (green) or repress (purple) protein expression from the respective mRNAs. *mRNA methylation at m6A and m5C decreases as cells progress towards senescence. mRNA, messenger RNA
