Fig. 8.

Structure of the stalled SARS CoV-2 RdRp complex with four molecules of Remdesivir. We show the structure of the stalled complex formed after incorporation of four molecules of RMP (magenta), labeled from 1 to 4 to give the order of incorporation. The RNA is in the pre-translocated state with the fourth RMP remaining in the active polymerase site (Pol site). The red arrow shows the likely steric clash between the cyano group of RMP with the beta carbon of S861 upon translocation. Drawn using Pymol from PDBID: 7L1F[2].