. 2021 Sep 27;49:39–62. doi: 10.1016/bs.enz.2021.07.001

Table 2.

Kinetic parameters for nucleotide incorporation.

Nucleotide	k_cat/K_m (μM^− 1 s^− 1)	k_cat (s^− 1)	K_m (μM)
UTP	2.3 ± 0.2	308 ± 17	130 ± 9
ATP	0.74 ± 0.16	240 ± 30	320 ± 50
RTP	1.29 ± 0.06	68 ± 2	53 ± 2

Rate constants for incorporation are from T.L. Dangerfield, N.Z. Huang, K.A. Johnson, Remdesivir is effective in combating COVID-19 because it is a better substrate than ATP for the viral RNA-dependent RNA polymerase. iScience (2020) 101849. Epub 2020/12/08. doi: 10.1016/j.isci.2020.101849. PubMed PMID: 33283177, PMCID: PMC7695572.