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. 2021 Sep 3;64(18):13622–13632. doi: 10.1021/acs.jmedchem.1c00995

Table 1. Chemical and Enzymatic Stabilities of (±)-1 and Its Two Enantiomers.

		(±)-1		(+)-1		(−)-1
stability		t_1/2 (h)	K_obs (h^–1)	t_1/2 (h)	K_obs (h^–1)	t_1/2 (h)	K_obs (h^–1)
chemical^a	pH 1.3	100.1 ± 3.1	0.007 ± 0.001
	pH 7.4	96.4 ± 1.6	0.007 ± 0.001
enzymatic^a	human plasma	60.5 ± 0.6	0.011 ± 0.006	58.2 ± 1.2	0.012 ± 0.001	70.3 ± 1.5	0.01 ± 0.002
	rat plasma	0.234 ± 0.003	2.96 ± 0.01	0.434 ± 0.002	1.60 ± 0.005	0.322 ± 0.01	2.15 ± 0.03

^a

Values are means ± standard deviation (SD) of three experiments.