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. 2021 Sep 3;64(18):13622–13632. doi: 10.1021/acs.jmedchem.1c00995

Table 2. σ1 and σ2 Binding Assays for Compound (±)-1, Its Enantiomers, and Precursor Compounds.

  Ki ± SD (nM)a
cmpd σ1 σ2
(±)-1b 13 ± 0.6 124 ± 15
(+)-1 64 ± 8.2 74 ± 8.9
(−)-1 16 ± 1.7 56 ± 6.4
(±)-HP-mIIb 2.9 ± 1.1 2.4 ± 0.7
(+)-4b 2.0 ± 0.6 32 ± 2.8
(−)-4b 3.0 ± 1.1 9.8 ± 1.8
HPb 2.7 ± 0.7 17 ± 0.7
a

Each value is the mean ± SD of at least two experiments performed in duplicate.

b

Data taken from ref (34).