Table 3. AT Levels of Oxidative Stress Biomarkers in the Study Population (n = 247)^a.

	total study participants (n = 247)b	participants without cancer (n = 224)	participants with any type of malignancy (n = 23)
	median (P25, P75)	median (P25, P75)	median (P25, P75)	P-valued
TBARS (μM)	3.10 (1.75, 7.69)	3.10 (1.73, 7.61)	3.00 (1.95, 11.3)	0.585
SOD (U/mL)	9.03 (4.26, 16.1)	8.67 (4.31, 15.3)	13.7 (3.90, 24.5)	0.154
HO-1 (ng/mL)	17.5 (6.89, 24.3)	17.3 (6.75, 23.8)	20.3 (10.9, 27.7)	0.117
GPx (U/mL)	11.7 (8.41, 17.0)	11.7 (8.41, 16.8)	11.1 (8.58, 18.1)	0.602
GRd (U/mL)	0.10 (0.05, 0.17)	0.10 (0.05, 0.17)	0.15 (0.09, 0.23)	0.030
total glutathione (nmol/mL)	16.8 (3.90, 33.8)	17.3 (4.44, 35.1)	7.46 (0.01, 28.8)	0.228
GSSG (nmol/mL)	1.15 (0.00, 9.97)	1.45 (0.00, 9.97)	0.00 (0.00, 2.25)	0.282
GSH (nmol/mL)	8.50 (2.05, 21.8)	9.03 (2.34, 21.1)	6.17 (0.00, 24.3)	0.248
GSSG/GSH	0.41 (0.00, 1.00)	0.41 (0.00, 1.00)	0.41 (0.00, 1.00)	0.981
8OHdGc (ng/mL)	0.54 (0.10, 1.72)	0.55 (0.15, 0.61)	0.45 (0.06, 1.72)	0.489

^aData are presented as median (percentile 25, percentile 75). Oxidative biomarkers: thiobarbituric acid reactive substances (TBARS); superoxide dismutase (SOD); heme oxygenase-1 (HO-1); glutathione peroxidase (GPx); glutathione reductase (GRd); oxidized glutathione (GSSG); reduced glutathione (GSH), 8-hydroxydeoxyguanosine.

^bA total of 247 participants with oxidative stress biomarkers measured in AT after excluding benign tumors and basal cell carcinomas (BCCs). During the 16-year follow-up period, 224 participants remained free of any type of tumor and 23 developed any type of malignancy.

^cMeasurement only available in 209 study participants.

^dP-value for the comparison between cancer and non-cancer cases using Mann–Whitney’s U test.