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. 2021 Sep 1;64(18):13279–13298. doi: 10.1021/acs.jmedchem.1c00224

Table 4. Binding Data of Compounds Selected from the Synthesized Library for 5-HT6, 5-HT3, 5-HT1A, 5-HT2A, 5-HT7, and D2Rs Suggest Marginal Affinity toward 5-HT1A, 5-HT2A, 5-HT7, and Dopamine D2 Receptors.

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      Ki [nM]a
compound Ar R 5-HT6R 5-HT3R 5-HT1AR 5-HT2AR 5-HT7R D2R
17 (FPPQ) 3-F-Ph H 3 0.93b 437 3005 2997 4392
18 3-Cl-Ph H 3 NT 773 1666 1794 1345
20 3-Me-Ph H 3 NT 760 4631 4139 2156
a

Mean Ki values (SEM ≤ 22%) based on at least three independent binding experiments.

b

Performed at Eurofins.