Table 4. Binding Data of Compounds Selected from the Synthesized Library for 5-HT6, 5-HT3, 5-HT1A, 5-HT2A, 5-HT7, and D2Rs Suggest Marginal Affinity toward 5-HT1A, 5-HT2A, 5-HT7, and Dopamine D2 Receptors.

|
Ki [nM]a |
||||||||
|---|---|---|---|---|---|---|---|---|
| compound | Ar | R | 5-HT6R | 5-HT3R | 5-HT1AR | 5-HT2AR | 5-HT7R | D2R |
| 17 (FPPQ) | 3-F-Ph | H | 3 | 0.93b | 437 | 3005 | 2997 | 4392 |
| 18 | 3-Cl-Ph | H | 3 | NT | 773 | 1666 | 1794 | 1345 |
| 20 | 3-Me-Ph | H | 3 | NT | 760 | 4631 | 4139 | 2156 |
Mean Ki values (SEM ≤ 22%) based on at least three independent binding experiments.
Performed at Eurofins.