Table 1. Experimental IC₅₀ Values (μM) of Compounds 7a–p and 11a–c toward HO-1 and HO-2.

			IC50 (μM)
compd	R1	R2	HO-1	HO-2	SI (HO-2/HO-1)
7a	Ph	H	110.0 ± 3.1	ND
7b	Ph	CH3	2.50 (mM)	ND
7c	3-BrPh	H	35.71 ± 1.20	ND
7d	4-IPh	H	8.34 ± 0.21	ND
7e	4-IPh	CH3	96.14 ± 1.44	ND
7f	PhCH2	H	57.60 ± 2.38	ND
7g	PhCH2	CH3	50.63 ± 1.84	ND
7h	PhCH2	PhCH2	64.80 ± 1.56	ND
7i	Ph(Ph)CH	CH3	0.90 ± 0.07	0.90 ± 0.05	1
7j	C5H9(Ph)CH	CH3	11.43 ± 0.97	ND
7k	C6H11(Ph)CH	CH3	26.84 ± 1.61	ND
7l	4-ClPh(Ph)CH	CH3	0.95 ± 0.04	1.2 ± 0.07	1.3
7m	3-BrPh(Ph)CH	CH3	0.90 ± 0.03	1.1 ± 0.04	1.2
7n	4-IPh(Ph)CH	CH3	0.95 ± 0.09	45.89 ± 1.67	48.3
7o	PhCH2OPh(Ph)CH	CH3	1.20 ± 0.11	11.19 ± 0.18	9.3
7p	4-BrPhCH2OPh(Ph)CH	CH3	8.0 ± 0.39	24.71 ± 0.14	3.1
11a	CH3		224.0 ± 8.10	ND
11b	Ph		31.0 ± 1.74	ND
11c	PhCH2		31.99 ± 1.48	ND
4b	Ph(Ph)CH	H	28.8 ± 1.41	14.4 ± 0.9	0.5
Azalanstatb			5.30 ± 0.4	24.40 ± 0.8	4.6

^aData are reported as IC₅₀ values in μM ± standard deviation (SD). Values are the mean of triplicate experiments.

^bData are from ref (23).