Table 1.
Effect of spironolactone on plasma electrolytes.
| SSWT (LS LK) | SSKcnj16−/− (LS LK) | SSKcnj16−/− (LS HK) | ||||
|---|---|---|---|---|---|---|
|
|
||||||
| Measurement | − Drug (N = 14) | + Drug (N = 6) | − Drug (N = 12) | + Drug (N = 6) | − Drug (N = 10) | + Drug (N = 6) |
|
| ||||||
| K+ (mmol/L) | 4.3 ± 0.2 | 5.2 ± 0.3* | 2.6 ± 0.2 | 2.3 ± 0.3 | 2.8 ± 0.1 | 4.0 ± 0.2* |
| Na+ (mmol/L) | 140 ± 1 | 145 ± 2* | 139 ± 1 | 140 ± 2 | 142 ± 2 | 144 ± 1 |
| Ca++ (mmol/L) | 1.31 ± 0.04 | 1.20 ± 0.06 | 1.29 ± 0.03 | 0.86 ± 0.11* | 1.21 ± 0.07 | 1.25 ± 0.06 |
| Cl− (mmol/L) | 106 ± 1 | 108 ± 2 | 112 ± 1 | 110 ± 5 | 114 ± 1 | 118 ± 1 |
| pH | 7.25 ± 0.03 | 7.28 ± 0.05 | 7.11 ± 0.02 | 6.97 ± 0.05* | 7.19 ± 0.03 | 7.12 ± 0.02 |
| ctHb (g/dL) | 16.8 ± 0.5 | 15.9 ± 0.9 | 16.3 ± 0.5 | 16.3 ± 0.8 | 11.4 ± 0.5 | 14.6 ± 0.3* |
| Creatinine (mg/dL) | 0.34 ± 0.07 | 0.37 ± 0.11 | 0.35 ± 0.08 | 1.74 ± 0.11* | --- | 0.37 ± 0.04 |