Fig. 7.

Heatmap displaying the ratio of group means of arcsinh-transformed median expression values for functional state markers in CD3⁻ FlowSOM metaclusters. A ratio of one (white) indicates that the DNP and T1DO group means are the same. A ratio greater than one (red) indicates DNP ​> ​T1DO, while a ratio less than one (blue) indicates DNP ​< ​T1DO. Black squares denote marker-population combinations with negligible or zero median expression values. Asterisks denote the statistical significance of the difference between group means for a functional state marker in a cell population based on two-way ANOVAs with q ​< ​0.1. NK: natural killer; mDC: myeloid dendritic cell; pDC: plasmacytoid dendritic cell. Two-way ANOVA with FDR q ​< ​0.1: ∗P ​< ​0.05; ∗∗P ​< ​0.01; ∗∗∗P ​< ​0.001; ∗∗∗∗P ​< ​0.0001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)