Table 1.
Demographic, clinical and global diffusion variables of healthy children born to normal mothers (CHNM), HIV uninfected children born to HIV infected mothers (HUC), and HIV infected children (HIC) born to HIV infected mothers.
| Demographic and clinical variables | CHNM (n = 18) | HUC (n = 8) | HIC (n = 22) | P values |
|---|---|---|---|---|
| Age (years) | 12 ± 2.8 | 10 ± 1.8 | 10 ± 2.3 | 0.06 |
| Gender (M/F) | 9/9 | 4/4 | 14/8 | |
| Education | 3.8 ± 2.04 | 4.25 ± 2.12 | 3.6 ± 2.41 | 0.63 |
| Ethnicity | Asian Indian | Asian Indian | Asian Indian | – |
| Peak HIV viral load (log copy/ml) | – | – | 483 ± 240 | – |
| CD4+ T-cell count at the time of MRI ( × 106/L) | – | – | 540 ± 298 | – |
| Global Gray Matter FA | 0.178 ± 0.0066 | 0.176 ± 0.0037 | 0.164 ± 0.0083 | 0.001 |
| Global White Matter FA | 0.325 ± 0.0142 | 0.310 ± 0.0058 | 0.297 ± 0.0161 | 0.001 |
| Global Gray Matter MD ( × 10−3) mm2/s | 0.930 ± 0.031 | 0.922 ± 0.019 | 0.958 ± 0.061 | 0.087 |
| Global White Matter MD( × 10−3) mm2/s | 0.873 ± 0.018 | 0.877 ± 0.022 | 0.909 ± 0.039 | 0.001 |