Table 2.
Mean (SD) Concentrations of Interleukin-2 (IL-2), IL-1β and Tumor Necrosis Factor (TNF)-α Over Time in PTSD and Non-PTSD Participants with Active tcVNS or Sham Stimulation.
IL-2 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Time | 0 | 4 | 6 | 8 | 10 | 12 | 14 | 15 | 18 | 19 | 22 |
PTSD Active | 0.17 (0.19) | 0.29 (0.19) | 0.19 (0.18) | 0.21 (0.16) | 0.20 (0.18) | 0.31 (0.22) | 0.18 (0.21) | 0.29 (0.19) | 0.34 (0.19) | 0.34 (0.19) | 0.39 (0.16) |
PTSD Sham | 0.28 (0.21) | 0.31 (0.18) | 0.23 (0.20) | 0.32 (0.18) | 0.30 (0.19) | 0.34 (0.19) | 0.40 (0.16) | 0.22 (0.19) | 0.20 (0.17) | 0.22 (0.17) | 0.21 (0.17) |
NonPTSD Active | 0.34 (0.22) | 0.23 (0.21) | 0.32 (0.22) | 0.34 (0.22) | 0.29 (0.24) | 0.37 (0.21) | 0.35 (0.20) | 0.23 (0.21) | 0.32 (0.23) | 0.22 (0.22) | 0.39 (0.19) |
NonPTSD Sham | 0.30 (0.21) | 0.25 (0.22) | 0.24 (0.22) | 0.19 (0.20) | 0.14 (0.15) | 0.24 (0.21) | 0.25 (0.21) | 0.27 (0.20) | 0.27 (0.20) | 0.24 (0.20) | 0.19 (0.18) |
IL-1β | |||||||||||
Time | 0 | 4 | 6 | 8 | 10 | 12 | 14 | 15 | 18 | 19 | 22 |
PTSD Active | 0.06 (0.04) | 0.09 (0.02) | 0.08 (0.04) | 0.08 (0.04) | 0.07 (0.04) | 0.08 (0.04) | 0.09 (0.03) | 0.11 (0.03) | 0.21 (0.27) | 0.12 (0.03) | 0.10 (0.00) |
PTSD Sham | 0.10 (0.08) | 0.07 (0.04) | 0.07 (0.04) | 0.08 (0.04) | 0.06 (0.03) | 0.03 (0.01) | 0.05 (0.01) | 0.11 (0.08) | 0.09 (0.05) | 0.11 (0.06) | 0.10 (0.05) |
NonPTSD Active | 0.05 (0.03) | 0.06 (0.04) | 0.08 (0.04) | 0.05 (0.04) | 0.08 (0.07) | 0.07 (0.04) | 0.05 (0.04) | 0.12 (0.08) | 0.14 (0.10) | 0.12 (0.08) | 0.12 (0.09) |
NonPTSD Sham | 0.08 (0.04) | 0.06 (0.03) | 0.07 (0.04) | 0.09 (0.04) | 0.07 (0.04) | 0.11 (0.08) | 0.09 (0.04) | 0.12 (0.06) | 0.11 (0.06) | 0.09 (0.04) | 0.08 (0.05) |
TNFα | |||||||||||
Time | 0 | 4 | 6 | 8 | 10 | 12 | 14 | 15 | 18 | 19 | 22 |
PTSD Active | 2.60 (0.85) | 2.27 (0.88) | 2.47 (0.76) | 2.41 (0.97) | 2.45 (0.60) | 2.32 (0.62) | 2.27 (0.82) | 2.44 (0.72) | 2.46 (0.64) | 2.55 (0.83) | 1.94 (0.17) |
PTSD Sham | 2.64 (1.35) | 2.84 (1.83) | 2.50 (1.38) | 2.64 (1.51) | 2.79 (1.58) | 2.55 (1.14) | 2.09 (0.53) | 2.71 (1.42) | 2.73 (1.65) | 2.59 (1.48) | 2.34 (1.46) |
NonPTSD Active | 2.90 (1.47) | 2.95 (1.53) | 2.89 (1.66) | 2.94 (1.56) | 2.94 (1.38) | 2.74 (1.15) | 2.54 (0.73) | 3.12 (1.52) | 3.17 (1.57) | 3.25 (1.26) | 2.54 (0.29) |
NonPTSD Sham | 2.22 (0.50) | 2.11 (0.65) | 2.10 (0.68) | 2.23 (0.42) | 2.30 (0.55) | 2.14 (0.52) | 2.23 (0.44) | 3.43 (2.80) | 3.43 (2.69) | 2.67 (1.05) | 2.12 (0.60) |