Table 2.
Sex differences in the genotype and allele distribution according to GAD diagnosis.
| Genotypes | Generalized Anxiety Disorder (GAD) |
Unadjusted OR (95%)/p∗ | Adjusted OR (95%)/p# | ||
|---|---|---|---|---|---|
| No | Yes | p | |||
| Total population | |||||
| rs2034310 SNP Genotype | |||||
| CC | 520 (55.4) | 114 (65.9) | 0.033 | 1 | 1 |
| CT | 366 (39.0) | 50 (28.9) | 0.623 (0.435-0.892)/0.010 | 0.609 (0.422-0.877)/0.008 | |
| TT | 52 (5.5) | 9 (5.2) | 0.789 (0.378-1.648)/0.529 | 0.738 (0.348-1.565)/0.428 | |
| Dominant model | |||||
| CC | 520 (55.4) | 114 (65.9) | 0.011 | 1 | 1 |
| CT/TT | 418 (44.6) | 59 (34.1) | 0.644 (0.458-0.904)/0.011 | 0.625 (0.442-0.885)/0.008 | |
| Allele- | |||||
| C | 1406 (74.9%) | 278 (80.0) | 0.397 | – | – |
| T | 470 (25.0) | 68 (19.6) | |||
| Women | |||||
| rs2034310 SNP Genotype | |||||
| CC | 277 (56.0) | 79 (62.2) | 0.357 | 1 | 1 |
| CT | 190 (38.4) | 40 (31.5) | 0.738 (0.484-1.127)/0.159 | 0.702 (0.457-1.127)/1.107 | |
| TT | 28 (5.7) | 8 (6.3) | 1.002 (0.439-2.285)/0.997 | 0.907 (0.393-2.096)/0.820 | |
| Dominant model | |||||
| CC | 277 (56.0) | 79 (62.2) | 0.243 | 1 | 1 |
| CT/TT | 218 (44.0) | 48 (37.8) | 0.772 (0.517-1.152)/0.205 | 0.729 (0.484-1.097)/0.129 | |
| Men | |||||
| rs2034310 SNP Genotype | |||||
| CC | 242 (54.8) | 35 (76.1) | 0.020 | 1 | 1 |
| CT | 176 (39.8) | 10 (21.7) | 0.393 (0.189-0.814)/0.012 | 0.404 (0.194-0.841)/0.015 | |
| TT | 24 (5.4) | 1 (2.2) | 0.288 (0.038-2.197)/0.230 | 0.308 (0.040-2.363)/0.257 | |
| Dominant model | |||||
| CC | 242 (54.8) | 35 (76.1) | 0.009 | 1 | 1 |
| CT/TT | 200 (45.2) | 11 (23.9) | 0.380 (0.188-0.768)/0.007 | 0.393 (0.194-0.797)/0.010 | |
Data are presented as number or proportion (%) and computed by χ2 tests comparing patients with GAD and controls. ∗ Unadjusted or # adjusted OR (95% CI/p) values were obtained from logistic regression analysis, and in the total population was adjusted for age, sex, and ethnicity and in women and men subpopulation was adjusted for age and ethnicity. p < 0.05 was considered as statistically significant. GAD: Generalized Anxiety Disorder.