Table 3.
Regression analyses for inflammatory markers at IPFU-2 predicting depression (BDI-II) at IPFU-3.
| Inflammatory Markers |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-6 (N = 445) |
CRP (N = 457) |
TNF (N = 391) |
|||||||||||||
| B | SE B | p | CI (95%) | B | SE B | p | CI (95%) | B | SE B | p | CI (95%) | ||||
| Age | 0.131 | 0.071 | 0.064 | 0.065 | −0.008, 0.270 | 0.103 | 0.070 | 0.050 | 0.140 | −0.034, 0.240 | 0.139 | 0.075 | 0.069 | 0.067 | −0.009, 0.287 |
| Gender | −0.510 | 0.428 | −0.043 | 0.234 | −1.352, 0.332 | −0.710 | 0.422 | −0.060 | 0.094 | −1.540, 0.120 | −0.940 | 0.450 | −0.081 | 0.037 | −1.824, −0.056 |
| Race | 0.758 | 0.540 | 0.054 | 0.162 | −0.305, 1.820 | 0.870 | 0.529 | 0.064 | 0.100 | −0.169, 1.909 | 0.301 | 0.569 | 0.023 | 0.597 | −0.819, 1.421 |
| Ethnicity | 0.827 | 1.278 | 0.022 | 0.518 | −1.685, 3.339 | 1.032 | 1.268 | 0.027 | 0.416 | −1.459, 3.523 | 1.660 | 1.413 | 0.043 | 0.241 | −1.119, 4.439 |
| SES | −0.334 | 0.264 | −0.047 | 0.207 | −0.854, 0.185 | −0.386 | 0.260 | −0.055 | 0.138 | −0.897, 0.125 | −0.375 | 0.286 | −0.054 | 0.191 | −0.938, 0.188 |
| BMI | −0.041 | 0.033 | −0.051 | 0.206 | −0.105, 0.023 | −0.066 | 0.034 | −0.081 | 0.053 | −0.132, 0.001 | −0.022 | 0.033 | −0.029 | 0.501 | −0.088, 0.043 |
| Physical Health | −0.095 | 0.030 | −0.148 | 0.002 | −0.154, −0.035 | −0.103 | 0.030 | −0.162 | 0.001 | −0.163, −0.044 | −0.065 | 0.032 | −0.104 | 0.043 | −0.128, −0.002 |
| MAP | −0.013 | 0.015 | −0.031 | 0370 | −0.043, 0.016 | −0.006 | 0.015 | −0.016 | 0.654 | −0.036, 0.022 | −0.015 | 0.016 | −0.036 | 0.336 | −0.047, 0.016 |
| Beta Blockers | −0.571 | 0.512 | −0.039 | 0.265 | −1.577, 0.435 | −0.378 | 0.503 | −0.026 | 0.453 | −1.367, 0.611 | −0.575 | 0.550 | −0.040 | 0.297 | −1.656, 0.507 |
| Calcium Blockers | 0.354 | 0.523 | 0.024 | 0.499 | −0.675, 1.383 | 0.553 | 0.510 | 0.039 | 0.279 | −0.450, 1.555 | 0.591 | 0.542 | 0.042 | 0.276 | −0.475, 1.658 |
| Statins | 0.751 | 0.454 | 0.060 | 0.099 | −0.142, 1.644 | 1.005 | 0.445 | 0.082 | 0.028 | 0.131, 1.879 | 0.639 | 0.485 | 0.052 | 0.188 | −0.314, 1.593 |
| ACE Inhibitors | −0.349 | 0.476 | −0.028 | 0.464 | −1.284, 0.587 | −0.443 | 0.465 | −0.036 | 0.340 | −1.357, 0.470 | −0.386 | 0.506 | −0.031 | 0.445 | −1.381, 0.608 |
| Benzodiazepines | 1.172 | 0.910 | 0.045 | 0.199 | −0.617, 2.962 | 0.907 | 0.865 | 0.035 | 0.312 | −0.853, 2.667 | 1.070 | 0.939 | 0.044 | 0.255 | −0.776, 2.917 |
| Hormones | 0.305 | 0.719 | 0.014 | 0.672 | −1.108, 1.717 | 0.592 | 0.710 | 0.028 | 0.405 | −0.805, 1.988 | −0.150 | 0.783 | 0.007 | 0.848 | −1.690, 1.390 |
| Aspirin | −0.771 | 0.445 | −0.063 | 0.084 | −1.645, 0.104 | −1.059 | 0.434 | −0.087 | 0.015 | −1.911, −0.207 | −0.736 | 0.464 | −0.062 | 0.114 | −1.645, 0.178 |
| Pain Medication | −1.636 | 0.671 | −0.090 | 0.015 | −2.956, −0.316 | −1.198 | 0.647 | −0.068 | 0.065 | −2.469, −0.073 | −1.557 | 0.674 | −0.090 | 0.021 | −2.882, −0.232 |
| NSAID | 0.160 | 0.530 | 0.010 | 0.763 | −0.882, 1.202 | 0.101 | 0.517 | 0.007 | 0.846 | −0.915, 1.117 | −0.408 | 0.549 | −0.028 | 0.6458 | −1.488, 0.672 |
| Steroids | 1.230 | 0.600 | 0.070 | 0.041 | −0.052, 2.409 | 1.006 | 0.600 | 0.057 | 0.095 | −0.174, 2.185 | 0.932 | 0.649 | 0.053 | 0.152 | −0.345, 2.210 |
| Anti-depressants | 1.568 | 0.561 | 0.105 | 0.005 | 0.465, 2.671 | 1.401 | 0.550 | 0.094 | 0.011 | 0321, 2.481 | 1.999 | 0.597 | 0.136 | <0.001 | 0.825, 3.172 |
| Sleep | −0.045 | 0.168 | −0.010 | 0.790 | −0.375, 0.285 | −0.036 | 0.165 | −0.008 | 0.82 | −0.361, 0.289 | −0.075 | 0.183 | −0.016 | 0.681 | −0.435, 0.285 |
| Caffeine | −0.167 | 0.122 | −0.048 | 0.168 | −0.407, 0.071 | −0.099 | 0.122 | −0.028 | 0.415 | −0.339, 0.140 | −0.082 | 0.134 | −0.023 | 0.541 | −0.344, 0.181 |
| BDI-II at IPFPU-2 | 0.611 | 0.045 | 0.563 | <0.001 | 0.522, 0.700 | 0.606 | 0.045 | 0.564 | <0.001 | 0.518, 0.693 | 0.619 | 0.049 | 0.586 | <0.001 | 0.523, 0.715 |
| Inflammation at IPFU-2 | 1.758 | 0.835 | 0.080 | 0.036 | 0.116, 3.400 | 0.935 | 0.429 | 0.083 | 0.030 | 0.095, 1.778 | 1.049 | 1.041 | 0.039 | 0.314 | −0.998, 3.097 |