Fig. 8.

Splenic T follicular helper (Tfh) cells of BTBR and B6 mice. BTBR mice have significantly higher Tfh cell population than B6 mice. Representative flow cytometric analyses are shown for Tfh cells (CD4⁺PD1⁺CXCR5⁺) in the spleens of B6 and BTBR mice (A). The frequencies and numbers of splenic Tfh cells of B6 and BTBR mice are in (B). Tfh cell population were identified based on PD1⁺CXCR5⁺ cell in CD3⁺CD4⁺ population. Data are representative of two independent experiments with 4 pairs of mice in each experiment. ∗ indicates a significant difference between the two strains. ∗ ​= ​p ​< ​0.05, ∗∗ ​= ​p ​< ​0.01, ∗∗∗ ​= ​p ​< ​0.001.