. 2020 Apr 13;4:100069. doi: 10.1016/j.bbih.2020.100069

Table 1.

B cell lineage phenotype (percentage).

Cell Stage (surface immunophenotype)^a	Spleen		Bone marrow
Cell Stage (surface immunophenotype)^a	B6	BTBR	B6	BTBR
PrePro B cell (B220^lowCD24^-CD43⁺IgM^-IgD^-)	1.77 ± 0.98	2.01 ± 1.23	1.83 ± 0.24	1.84 ± 0.29
Pro B cell (B220^lowCD19⁺CD24⁺CD43⁺CD249^-	2.78 ± 0.52	3.99 ± 1.41	45.65 ± 2.07	48.64 ± 2.59^b
PreB cell (B220^lowCD19⁺CD24⁺CD43^lowCD249⁺)	0.25 ± 0.05	0.24 ± 0.06	1.26 ± 0.45	0.98 ± 0.49
Immature B cell (B220⁺CD19⁺CD24⁺CD43^- IgM⁺IgD^-)	1.2 ± 0.47	0.41 ± 0.16^b	1.53 ± 0.46	1.23 ± 0.45
Transitional B cell (B220⁺CD19⁺CD24⁺CD43^- IgM⁺IgD^low)	7.5 ± 0.49	4.89 ± 0.88^b	3.07 ± 0.46	2.75 ± 0.91
Mature B cell (B220⁺ CD19⁺CD24⁺CD43^- IgM⁺ IgD⁺)	45.8 ± 2.05	37.24 ± 3.23^b	10.72 ± 1.67	7.53 ± 2.17^b
Plasmablast (B220^lowCD138⁺CXCR4⁺ MHCII⁺)	0.41 ± 0.06	1.18 ± 1.92	0.13 ± 0.04	0.21 ± 0.03^b
Plasma cell (CD19^-CD138⁺CXCR4⁺)	0.26 ± 0.06	0.47 ± 0.18^b	0.58 ± 0.15	0.93 ± 0.2^b
Plasma cell -Short lived (CD19^-CD138⁺CXCR4⁺CD93⁺)	0.005 ± 0.004	0.030 ± 0.057	0.06 ± 0.04	0.06 ± 0.04
Plasma cell-Long lived (CD19^-CD138⁺CXCR4⁺CD93^-)	0.24 ± 0.07	0.37 ± 0.36	0.52 ± 0.15	0.85 ± 0.16^b

The immunophenotyping of B cell and plasma cell development was based on references (Allman and Pillai, 2008; Shapiro-Shelef and Calame, 2005).

Significant difference between B6 and BTBR.