Table 3.

Predictor for Efficacy in PD-1 or PD-L1 Inhibitors

PFS	Univariate Analysis			Multivariate Analysis
	OR	95% CI	p Value	OR	95% CI	p Value
Cachexia vs. noncachexia	2.74	1.72–4.37	<0.001	2.46	1.52–3.98	<0.001
PD-L1 TPS < 50% vs. ≥ 50%	2.00	1.28–3.23	0.002	1.62	1.01–2.58	0.044
BMI ≥ 25 vs. BMI < 25	0.87	0.49–1.56	0.539
Age ≥ 75 vs. < 75 y	0.67	0.36–1.22	0.193
Male vs. female	0.68	0.41–1.13	0.142
Smoking yes vs. no	0.86	0.44–1.67	0.655
Nonsquamous vs. squamous	0.51	0.28–0.92	0.026	0.50	0.28–0.91	0.023
ECOG-PS 0 vs. 1	0.74	0.38–1.44	0.380

OR, odds ratio; PFS, progression-free survival; PD-L1, programmed death-ligand 1; PD-1, programmed cell death 1; TPS, tumor proportion score; BMI, body mass index; ECOG, Eastern Cooperative Oncology Group; PS, performance status; CI, confidence interval.