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. 2020 Sep 3;1(4):100093. doi: 10.1016/j.jtocrr.2020.100093

Figure 2.

Figure 2

Pharmacodynamics and response. (A) Pharmacodynamics of arginine and citrulline in patients treated with ADIPemCis. Serum arginine and citrulline are revealed by week of treatment (mean ± SEM). (B) Serum levels of anti–ADI-PEG 20 antibodies in all patients by week of ADIPemCis (mean ± SEM). (C) Waterfall plot of response by modified RECIST to ADIPemCis. (D) Spider plots revealing response duration to ADIPemCis. Ab, antibody; ADI, arginine deiminase; ADIPemCis, ADI-PEG 20 with pemetrexed and cisplatin; B, biphasic; E, epithelioid; PEG, PEGylated; RECIST, Response Evaluation Criteria in Solid Tumors; S, sarcomatoid.