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. 2020 Jan 26;2:100040. doi: 10.1016/j.bbih.2020.100040

Fig. 4.

Fig. 4

VBC and PBM attenuates the overexpression of IL1β, IL6 and TNF-α at protein levels induced a significant increase in the expression of IL10. Effect of VBC and PBM on the expression of IL1β, IL6, TNF-α and IL10 in the spinal trigeminal nucleus of chronic constrictive injury of infraorbital nerve rats; Correspondingly, A Western blot analysis demonstrated that IL-1β (B), IL6 (C) and TNF-α (D) levels were increased in the spinal trigeminal nucleus of the CCI-IoN group compared with those in control groups (naive and sham) (#p ˂ 0.05) and decreased in the CCI-IoN ​+ ​VBC, CCI-IoN ​+ ​PBM and CCI-IoN ​+ ​VBC ​+ ​PBM groups compared with those in CCI-IoN group (**p ˂ 0.01 and ***p ˂ 0.001); in E IL10 level didn’t alter after CCI-IoN compared with the control groups (naive and sham) and increased after the treatments compared with the others groups (p ​≤ ​0.05). Data were normalized from naive rats’ IL1β, IL6, TNF-α and IL10 expression. Data are presented as the mean ​± ​SEM of 5 animals per group.