Table 1.

Risk of MS or depression in genetically susceptible individuals.

	#SNPs	OR (95% CI)	p value	p value for intercept	#SNPs	OR (95% CI)	p value	p value for intercept
	Full-set				Remove palindromic SNPs
Risk of MS in persons genetically susceptible for depression
IVW	96	1.03 (0.80–1.34)	0.81		83	1.03 (0.78–1.37)	0.83
Maximum likelihood	96	1.03 (0.79–1.35)	0.81		83	1.03 (0.78–1.37)	0.82
MR-Egger	96	0.79 (0.27–2.36)	0.68	0.63	83	0.62 (0.20–1.93)	0.41	0.36
Weighted median	96	1.06 (0.80–1.40)	0.69		83	0.99 (0.74–1.33)	0.94
Adjusted for BMI	39	1.26 (0.77–2.05)	0.34
Adjusted for smoking	79	1.02 (0.76–1.37)	0.38
Adjusted for alcohol consumption	79	1.00 (0.75–1.34)	0.77
Adjusted for vitamin-D	95	1.00 (0.76–1.31)	0.98
Risk of depression in persons genetically susceptible for MS
IVW	168	1.00 (0.99–1.01)	0.24		148	1.00 (0.99–1.01)	0.34
Maximum likelihood	168	1.00 (0.99–1.01)	0.14		148	1.00 (0.99–1.01)	0.22
MR-Egger	168	1.01 (0.98–1.04)	0.34	<0.001	148	1.01 (0.98–1.04)	0.37	<0.001
Weighted median	168	1.00 (0.99–1.01)	0.33		148	1.00 (0.99–1.01)	0.46

IVW: inverse variance weighted; OR: odd ration; CI: confidence interval; BMI: body mass index