Figure 2.

Neuroinflammation and neuronal loss is a non cell-autonomous effect of low Glut1 in ECs. Depicted are representative thalamic sections of a control adult mouse wild-type for the Slc2a1 gene and an age-matched mutant engineered to be haploinsufficient for the gene specifically in ECs.

Note profound astrocytosis and fewer NeuN-positive puncta representing neurons in the mutant sample.