Table 3.
Changes in Positive Rates of NSCLC in Selected Hospitals During 2010 to 2019 in Mainland People’s Republic of China
| Driver Gene | Sample Type | Methods | 2010 | 2011 | Positive Rates of Driver Genes by Year |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | |||||
| EGFR | FFPE | qPCR | 39.0 | 39.1 | 38.7 | 40.4 | 40.6 | 43.5 | 44.5 | 43.7 | 43.3 | 44.1 |
| NGS | — | — | — | 36.3 | 39.7 | 42.7 | 44.6 | 41.9 | ||||
| Sanger sequencing | 34.2 | 31.9 | ||||||||||
| EGFR | Blood | Super-ARMS | — | — | — | — | 22.9 | 23.8 | 22.4 | 23.5 | ||
| NGS | — | — | — | — | — | 21.7 | 22.0 | 21.4 | ||||
| ALK | FFPE | qRT-PCR | 5.9 | 6.2 | 6.6 | 7.5 | 7.5 | 6.9 | 6.1 | 6.1 | ||
| FISH | 6.8 | 7.2 | 6.6 | 10.5 | 11.9 | 13.5 | 12.2 | 13.7 | 10.1 | 13.2 | ||
| Vetana-D5F3 IHC | — | 7.2 | 6.6 | 6.4 | 6.4 | 7.0 | 7.2 | 6.9 | ||||
| NGS | — | — | — | 3.1 | 3.8 | 4.1 | 5.5 | 5.1 | ||||
| ROS1 | FFPE | qRT-PCR | — | 1.6 | 1.7 | 1.3 | 1.4 | 1.8 | 1.6 | 1.8 | ||
| FISH | — | — | 4.2 | 3.5 | 4.3 | 4.2 | 4.6 | 4.1 | ||||
| NGS | — | — | — | — | 1.4 | 1.4 | 1.5 | 1.2 | ||||
Note: Values are given in %.
FFPE, formalin-fixed, paraffin-embedded; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; NGS, next-generation sequencing; qPCR, quantitative real-time polymerase chain reaction; qRT-PCR, quantitative reverse-transcript polymerase chain reaction; Super-AMRS, superamplification refractory mutation system.