Supplemental Fig. 5.

Deletion of Ido1 exacerbates clinical scores of EAE. A, B, Experimental autoimmune encephalomyelitis (EAE) was induced in C57BL/6J (n ​= ​11), commercial Ido1^KO (n ​= ​9), Ido1 total knockout mice prepared in house (Ido1^TK; n ​= ​11) and Ido2^−/− mice (n ​= ​11). Clinical scores of disease (A) as well as analysis of slope for disease progression (B) are shown. The slope for Ido1^KO and Ido1^TK mice are similar and greater than that of a C57BL/6 (a) and Ido2^−/− (b) mice (both P values ​< ​0.01).