Fig. 4.

The effect of genotype on spinal cord pathology following EAE induction. Spinal cord sections were stained with Oil Red O and demyelination percentage was quantified using ImageJ software. Representative thoracic sections of each genotype are shown. Average demyelination scores were taken from at least four mice per strain. The percentage of demyelination for each anatomical location was estimated by averaging results obtained from 3–5 sections per mouse. The values of all sections were averaged for each mouse. Therefore, each point represent the average lesion load expressed as the percentage of total white matter for individual mice. Scale bar ​= ​200 ​μm. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)