Table 2.
Patients Characteristics According to Different KRAS Point Mutations
| Patients Characteristics | G12C (N = 374) | G12V (N = 168) | G12D (N = 131) | G12A (N = 62) | G12S (N = 25) | G12F (N = 11) | G13C (N = 45) | G13D (N = 31) | Other (N = 44) | Total (N = 901) |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex | ||||||||||
| Male | ||||||||||
| N (%) | 253 (67.6) | 107 (63.7) | 92 (70.2) | 38 (61.3) | 13 (52.0) | 5 (45.5) | 35 (77.8) | 21 (67.7) | 29 (65.9) | 593 (66.6) |
| Female | ||||||||||
| N (%) | 121 (32.4) | 61 (36.3) | 39 (29.8) | 24 (38.7) | 12 (48.0) | 6 (54.5) | 10 (22.2) | 10 (32.3) | 15 (34.1) | 298 (33.4) |
| Age (years) | ||||||||||
| Median | 61.01 | 61.06 | 64.28 | 62.62 | 61.36 | 61.34 | 59.90 | 60.16 | 59.40 | 61.61 |
| Range | 38.9–87.7 | 30.0–87.2 | 32.6–85.2 | 41.3–82.4 | 45.3–84.4 | 46.4–80.5 | 39.7–83.3 | 41.8–80.0] | 39.3–82.5 | 30.0–87.7 |
| Asian origin | ||||||||||
| Yes | ||||||||||
| N (%) | 4 (1.2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 (0.4) |
| No | ||||||||||
| N (%) | 329 (98.8) | 152 (100.0) | 115 (100.0) | 57 (100.0) | 21 (100.0) | 9 (100.0) | 38 (100.0) | 26 (100.0) | 40 (100.0) | 787 (88.3) |
| Missing | ||||||||||
| N | 41 | 16 | 16 | 5 | 4 | 2 | 7 | 5 | 4 | 100 |
| Smoking | ||||||||||
| Nonsmoker | ||||||||||
| N (%) | 12 (3.2) | 9 (5.4) | 19 (14.5) | 1 (1.6) | 0 | 0 | 1 (2.2) | 0 | 0 | 42 (4.7) |
| Smoker/former smoker | ||||||||||
| N (%) | 362 (96.8) | 159 (94.6) | 112 (85.5) | 61 (98.4) | 25 (100.0) | 11 (100.0) | 44 (97.8) | 31 (100.0) | 44 (100.0) | 849 (95.3) |
| PS | ||||||||||
| 0–1 | ||||||||||
| N (%) | 243 (68.3) | 119 (73.0) | 91 (71.7) | 42 (71.2) | 14 (63.6) | 9 (81.8) | 35 (83.3) | 15 (55.6) | 27 (65.9) | 595 (66.8) |
| 2 | ||||||||||
| N (%) | 84 (23.6) | 36 (22.1) | 27 (21.3) | 13 (22.0) | 5 (22.7) | 1 (9.1) | 7 (16.7) | 12 (44.4) | 12 (29.3) | 197 (22.1) |
| 3–4 | ||||||||||
| N (%) | 29 (8.1) | 8 (4.9) | 9 (7.1) | 4 (6.8) | 3 (13.6) | 1 (9.1) | 0 | 0 | 2 (4.9) | 56 (6.3) |
| Missing | ||||||||||
| N | 18 | 5 | 4 | 3 | 3 | 0 | 3 | 4 | 3 | 43 |
| Histology | ||||||||||
| Squamous | ||||||||||
| N (%) | 5 (1.3) | 2 (1.2) | 3 (2.3) | 0 | 0 | 0 | 0 | 0 | 0 | 10 (1.1) |
| Adenocarcinoma | ||||||||||
| N (%) | 310 (82.9) | 135 (80.4) | 104 (79.4) | 54 (87.1) | 20 (80.0) | 8 (72.7) | 40 (88.9) | 26 (83.9) | 37 (84.1) | 734 (82.4) |
| Large cell | ||||||||||
| N (%) | 8 (2.1) | 8 (4.8) | 2 (1.5) | 1 (1.6) | 0 | 0 | 2 (4.4) | 2 (6.5) | 3 (6.8) | 26 (2.9) |
| Other | ||||||||||
| N (%) | 51 (13.6) | 23 (13.7) | 22 (16.8) | 7 (11.3) | 5 (20.0) | 3 (27.3) | 3 (6.7) | 3 (9.7) | 4 (9.1) | 121 (13.6) |
PS, performance status.