Table 5.
Multivariate Analysis of the Predictive Factors for OS in the Patients With Advanced-Stage (IIIb or IV) Nonsquamous NSCLC With Kras Mutations
| Factors | No. of Patients | OS (mo) | Univariate Analysis |
Multivariate Analysis |
|
|---|---|---|---|---|---|
| P | HR (95% CI) | P | |||
| Sex | |||||
| Female | 38 | 7.3 | 1 | ||
| Male | 105 | 5.7 | 0.150 | 0.96 (0.55–1.68) | 0.887 |
| Smoking history | |||||
| Nonsmokers | 46 | 7.4 | 1 | ||
| Smokers | 97 | 5.3 | 0.039 | 1.69 (0.99–2.90) | 0.057 |
| Stage | |||||
| IIIb | 16 | 32.2 | 1 | ||
| IV | 127 | 5.7 | 0.002 | 2.69 (1.30–5.59) | 0.008 |
| Histology | |||||
| Adenocarcinoma | 122 | 7.4 | 1 | ||
| Pleomorphic or sarcomatoid | 11 | 2.5 | 1.82 (0.90–3.71) | 0.098 | |
| NSCLC-NOS | 10 | 1.3 | <0.001 | 3.12 (1.53–6.36) | 0.002 |
| Kras mutations | |||||
| G12C | 44 | 7.7 | 1 | ||
| G12D | 40 | 11.7 | 1.40 (0.84–2.35) | 0.197 | |
| G12V | 24 | 5.2 | 2.47 (1.39–4.39) | 0.002 | |
| G12A or S or R or others | 35 | 5.7 | 0.019 | 1.54 (0.90–2.63) | 0.119 |
CI, confidence interval; HR, hazard ratio; NOS, not otherwise specified; OS, overall survival.