Table 2.
List of Chromosomal Location of Intergenic Translocations With Potential ROS1 Fusion Partners
| No. | Year Published in Print/Presented |
Chromosomal Location | Potential Fusion Partner Gene | RET Exon Fusion | Response to ALK TKI At the Time of Publication | Tumor Source | Method of Detection | Variant Frequency in Tumor | FISH/IHC | References |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2019 | 6q22.1 | DCBLD1c | R35 | NR | FFPE | DNA NGS | NR | NR/NR | Xu et al.34 |
FFPE, formalin-fixed paraffin embedded; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; NGS, next-generation sequencing; NR, not reported; TKI, tyrosine kinase inhibitor.
c
DCBLD1 intergenic rearrangement–ROS1 was identified as a potential resistance RTK fusion to osimertinib in an EGFR+ patient with NSCLC (Del 19, T790M) in addition to RP11-565P22.6-NTRK1 fusion.