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. 2021 Sep 13;11:723345. doi: 10.3389/fonc.2021.723345

Table 1.

Demographic and clinical characteristics of the enrolled patients.

Characteristics Total Population N0 N1 N2 N3a N3b
(n = 185) (n = 49) (n = 31) (n = 31) (n = 52) (n = 22)
Age, median (range) 62 (22–86) 61 (28–81) 63 (36–80) 62 (24–73) 62 (26–86) 66 (22–79)
Gender, n(%) 185 49 31 31 52 22
Male 127 (68.6) 40 (81.6) 22 (71.0) 20 (64.5) 32 (61.5) 13 (59.1)
Female 58 (31.4) 9 (18.4) 9 (29.0) 11 (35.5) 20 (38.5) 9 (40.9)
Histopathological Type, n (%)
adenocarcinoma 144 (77.8) 42 (85.7) 26 (83.9) 25 (80.6) 41 (78.8) 10 (45.5)
mixed adenocarcinoma 41 (22.2) 7 (14.3) 5 (16.1) 6 (19.4) 11 (21.2) 12 (54.5)
Lauren Type, n (%)
intestinal type 64 (34.6) 23 (46.9) 14 (45.2) 12 (38.7) 14 (26.9) 1 (4.5)
diffuse type 51 (27.6) 14 (28.6) 5 (16.1) 9 (29.0) 13 (25) 10 (45.5)
mixed type 70 (37.8) 12 (24.5) 12 (38.7) 10 (32.3) 25 (48.1) 11 (50.0)
Differentiation, n (%)
low 85 (45.9) 18 (36.7) 10 (32.3) 12 (38.7) 28 (53.8) 17 (77.3)
middle-low 58 (31.4) 11 (22.4) 10 (32.3) 13 (41.9) 19 (36.5) 5 (22.7)
middle 36 (19.5) 16 (32.7) 11 (35.4) 5 (16.1) 4 (7.7) 0 (0.0)
high 6 (3.2) 4 (8.2) 0 (0.0) 1 (3.3) 1 (2.0) 0 (0.0)
Vascular Tumor Thrombus, n (%)
not contain 34 (18.4) 25 (51) 8 (25.8) 1 (3.3) 0 (0.0) 0 (0.0)
contain 126 (68.1) 12 (24.5) 18 (58.1) 25 (80.6) 51 (98.1) 20 (91.0)
uncertain 22 (11.9) 12 (24.5) 4 (12.9) 5 (16.1) 0 (0.0) 1 (4.5)
multiple tumors 3 (1.6) 0 (0.0) 1 (3.2) 0 (0.0) 1 (1.9) 1 (4.5)
Infiltration depth, n (%)
lamina propria or submucosa 31 (16.8) 20 (40.8) 5 (16.1) 3 (9.7) 2 (3.8) 1 (4.5)
muscularis propria 23 (12.4) 9 (18.4) 6 (19.4) 3 (9.7) 4 (7.7) 1 (4.5)
subserosa 54 (29.2) 10 (20.4) 9 (29.0) 13 (41.9) 17 (32.7) 5 (22.8)
serosal layer 46 (24.8) 7 (14.3) 4 (12.9) 8 (25.8) 21 (40.4) 6 (27.3)
fat tissue outside the serosal layer etc. 31 (16.8) 3 (6.1) 7 (22.6) 4 (12.9) 8 (15.4) 9 (40.9)
Nerve invasion, n (%)
+ 104 (56.2) 16 (32.7) 17 (54.8) 19 (61.3) 37 (71.1) 15 (68.2)
61 (33.0) 30 (61.2) 14 (45.2) 7 (22.6) 7 (13.5) 3 (13.6)
uncertain 20 (10.8) 3 (6.1) 0 (0.0) 5 (16.1) 8 (15.4) 4 (18.2)
SUVmax_tumor, mean (std) 7.76 (5.93) 5.55 (4.41) 8.66 (5.61) 8.34 (5.02) 9.51 (7.57) 6.48 (3.87)
SUVmax_LN, mean (std) 2.92 (3.72) 1.56 (2.28) 3.32 (3.73) 3.07 (3.17) 3.58 (4.96) 3.60 (2.62)
maximum diameter, mean (std) 4.81 (2.97) 3.76 (2.48) 4.14 (2.43) 4.82 (2.10) 4.95 (2.85) 7.77 (3.89)