. 2021 Jan 7;12:100199. doi: 10.1016/j.bbih.2021.100199

Table 2.

Findings of D2R expression in LYM of patients with SCZ.

Reference	Study	n	Sample	Methodology	Clinical features	Findings
Bondy et al., 1985	Healthy controls	40	LYM	Receptor binding assay	ND	Increased D2-like binding (of 3H-spiperone)
	Unmedicated SCZ patients	27
	Psychiatric control group	16
Zvara et al., 2005	Healthy controls	10	PBLs	qRT-PCR	PANSS, CGIS, GAF, Duration of illness, Medication	D2R mRNA over-expressed
Zvara et al., 2005	Drug-free/Drug-naïve SCZ patients	13	PBLs	qRT-PCR	PANSS, CGIS, GAF, Duration of illness, Medication	D2R mRNA over-expressed
Boneberg et al., 2006	Healthy controls	10	Leukocyte population PBMCs	qRT-PCR	ND	D2R is not express
Boneberg et al., 2006	SCZ patients	10	Leukocyte population PBMCs	qRT-PCR	ND	D2R is not express
Yao et al., 2008	Healthy controls	26	PBMCs	qRT-PCR	Duration of treatment	No differences in D2R mRNA
Yao et al., 2008	First-hospitalized SCZ patients	30	PBMCs	qRT-PCR	Duration of treatment	No differences in D2R mRNA
Brito-Melo et al., 2012	Healthy controls	20	LYM (CD4, CD8)	Flow-cytometry	CGIS, BPRS, PANSS, AIMS, Duration of illness and hospitalization, Dose of antipsychotic	Increased percentages of CD8⁺D2R⁺ cells
	SCZ patients	40				Lower percentages of CD4⁺D2R⁺ cells
						BPRS and PANSS positively related to CD8⁺D2R⁺ cells
						AIMS positively related to CD4⁺D2R⁺ cells
Liu et al., 2013	Healthy controls	30	PBLs	qRT-PCR	PANSS, Duration of illness	No differences in D2R mRNA
	Acute SCZ patients	25				Significant relationship between D2R mRNA and positive symptom score of PANSS in acute SCZ patients
	Chronic SCZ patients	27
Ahmadian et al., 2014	Healthy controls	20	PBLs	RT-PCR	ND	D2R expressed in all groups but no differences in mRNA
	Drug-naïve SCZ patients	5
	Drug-free SCZ patients (» 3 months)	15
	Drug-medicated SCZ patients (» 3 years)	22
Cui et al., 2015	Healthy controls	30	T LYM	qRT-PCR	Duration of treatment, Medication, Age of onset, PANSS	No differences in D2R mRNA
	Psychotic not otherwise specified patients	18				Significant positive correlation between D2R mRNA vs excited factor of PANSS in SCZ/schizophreniform patients
	SCZ/schizophreniform patients	14

Abbreviations: Positive and Negative Syndrome Scale (PANSS) for Schizophrenia, Clinical Global Impression Scale (CGIS), Global Assessment of Functioning (GAF), Brief Psychiatric Rating Scale (BPRS), Abnormal Involuntary Movement Scale (AIMS). No Data (ND).