Table 2.
Proportion of infants demonstrating positive CD68 and HLA-DP,DQ,DR in the parenchyma of different regions of the brain comparing amongst diagnostic groups.
| BRAIN REGION | Proportion cases positive CD68 in parenchyma (%) |
P-value; Fischer’s∗ |
Proportion cases positive HLA in parenchyma (%) |
P-value; Fischer’s∗ |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Infants (n = 28) |
eSUDI (n = 7) | SIDS I (n = 8) | SIDS II (n = 13) | eSUDI vs SIDS I | eSUDI vs SIDS II | SIDS I vs SIDS II | All Infants (n = 28) | eSUDI (n = 7) | SIDS I (n = 8) | SIDS II (n = 13) | eSUDI vs SIDS I | eSUDI vs SIDS II | SIDS I vs SIDS II | |
| Basal Ganglia | ||||||||||||||
| Caudate nucleus (head) | 14/26 (54) | 3/7 (43) | 3/6 (50) | 8/13 (62) | 1.00 | 0.64 | 1.00 | 5/26 (19) | 2/7 (29) | 1/6 (17) | 2/13 (15) | 1.00 | 0.59 | 1.00 |
| Claustrum | 4/26 (15) | 1/6 (17) | 1/7 (14) | 2/13 (15) | 1.00 | 1.00 | 1.00 | 3/26 (12) | 2/6 (33) | 1/7 (14) | 0/13 (0) | 0.56 | 0.09 | 0.35 |
| Globus pallidus (inner + outer) | 9/26 (35) | 1/6 (17) | 3/7 (43) | 5/13 (39) | 0.56 | 0.61 | 1.00 | 1/26 (4) | 1/6 (17) | 0/7 (0) | 1/13 (8) | 0.46 | 1.00 | 1.00 |
| Lentiform nucleus | 17/26 (65) | 5/6 (83) | 4/7 (57) | 8/13 (62) | 0.56 | 0.61 | 1.00 | 8/26 (31) | 2/6 (33) | 3/7 (43) | 3/13 (23) | 1.00 | 1.00 | 0.61 |
| Putamen | 25/27 (93) | 6/7 (86) | 7/7 (100) | 12/13 (92) | 1.00 | 1.00 | 1.00 | 15/27 (56) | 3/7 (43) | 6/7 (86) | 6/13 (46) | 0.27 | 1.00 | 0.16 |
| Striatum | 23/26 (88) | 5/7 (71) | 6/6 (100) | 12/13 (92) | 0.46 | 0.27 | 1.00 | 11/26 (42) | 3/7 (43) | 2/6 (33) | 6/13 (46) | 1.00 | 1.00 | 1.00 |
| Cerebellum | ||||||||||||||
| Dentate Nucleus | 10/28 (36) | 2/6 (33) | 1/8 (13) | 7/13 (54) | 0.57 | 0.37 | 0.09 | 8/28 (29) | 2/7 (29) | 2/8 (25) | 4/13 (31) | 1.00 | 1.00 | 1.00 |
| Internal granular layer | 5/28 (18) | 2/7 (29) | 2/8 (25) | 1/13 (8) | 1.00 | 0.27 | 0.53 | 2/28 (7) | 0/7 (0) | 1/8 (13) | 1/13 (8) | 1.00 | 1.00 | 1.00 |
| Molecular layer | 14/28 (50) | 3/7 (43) | 4/8 (50) | 7/13 (54) | 1.00 | 1.00 | 1.00 | 7/28 (25) | 1/7 (14) | 5/8 (63) | 1/13 (8) | 0.12 | 1.00 | 0.01 |
| White Matter | 20/28 (71) | 6/7 (86) | 3/8 (38) | 11/13 (85) | 0.12 | 1.00 | 0.06 | 18/28 (64) | 5/7 (71) | 5/8 (63) | 8/13 (62) | 1.00 | 1.00 | 1.00 |
| Cortical regions | ||||||||||||||
| Anterior superior frontal cortex | 13/26 (50) | 5/7 (71) | 1/6 (17) | 7/13 (54) | 0.10 | 0.64 | 0.18 | 8/26 (31) | 1/7 (14) | 2/6 (33) | 5/13 (38) | 0.56 | 0.35 | 1.00 |
| Posterior frontal cortex | 14/27 (52) | 5/7 (71) | 3/7 (43) | 6/13 (46) | 0.59 | 0.37 | 1.00 | 14/27 (52) | 4/7 (57) | 2/7 (29) | 8/13 (62) | 0.56 | 1.00 | 0.35 |
| Insula cortex | 3/26 (12) | 0/7 (0) | 1/7 (14) | 2/13 (15) | 1.00 | 1.00 | 1.00 | 6/26 (23) | 2/6 (33) | 2/7 (29) | 2/13 (15) | 1.00 | 0.56 | 0.59 |
| Occipital cortex | 9/27 (33) | 3/7 (43) | 2/7 (29) | 4/13 (31) | 1.00 | 0.65 | 1.00 | 13/27 (48) | 1/7 (14) | 3/7 (43) | 9/13 (69) | 0.56 | 0.06 | 0.36 |
| Parietal cortex | 15/27 (56) | 4/7 (57) | 4/7 (57) | 7/13 (54) | 1.00 | 1.00 | 1.00 | 10/27 (37) | 3/7 (43) | 2/7 (29) | 5/13 (38) | 1.00 | 1.00 | 1.00 |
| Temporal cortex | 15/27 (56) | 5/7 (71) | 3/7 (43) | 7/13 (54) | 0.59 | 0.64 | 1.00 | 3/28 (11) | 1/7 (14) | 1/8 (13) | 1/13 (8) | 1.00 | 1.00 | 1.00 |
| Hippocampus | ||||||||||||||
| Cornu ammonis 4 | 11/28 (39) | 4/7 (57) | 2/8 (11) | 5/13 (38) | 0.32 | 0.64 | 0.66 | 6/28 (21) | 1/7 (14) | 2/8 (25) | 3/13 (23) | 1.00 | 1.00 | 1.00 |
| Cornu ammonis 3 | 2/28 (7) | 1/7 (14) | 0/8 (0) | 1/13 (8) | 0.47 | 1.00 | 1.00 | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 |
| Cornu ammonis 2 | 1/28 (4) | 0/7 (0) | 0/8 (0) | 1/13 (8) | 1.00 | 1.00 | 1.00 | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 |
| Cornu ammonis 1 | 1/28 (4) | 0/7 (0) | 0/8 (0) | 1/13 (8) | 1.00 | 1.00 | 1.00 | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 |
| Dentate gyrus | 9/28 (32) | 2/7 (29) | 0/8 (0) | 7/13 (54) | 0.20 | 0.37 | 0.02 | 2/28 (7) | 0/7 (0) | 1/8 (13) | 1/13 (8) | 1.00 | 1.00 | 1.00 |
| Parahippocampal gyrus | 12/28 (43) | 5/7 (71) | 1/8 (13) | 6/13 (46) | 0.04 | 0.37 | 0.17 | 1/28 (4) | 1/7 (14) | 0/8 (0) | 1/13 (8) | 0.47 | 1.00 | 1.00 |
| Subiculum | 9/28 (32) | 4/7 (57) | 0/8 (0) | 5/13 (38) | 0.03 | 0.64 | 0.11 | 3/28 (11) | 2/7 (29) | 0/8 (0) | 1/13 (8) | 0.20 | 0.27 | 1.00 |
| Medulla (rostral) | ||||||||||||||
| Arcuate nucleus | 3/28 (11) | 0/7 (0) | 1/8 (13) | 2/13 (15) | 1.00 | 0.52 | 1.00 | 5/28 (18) | 1/7 (14) | 1/8 (13) | 3/13 (23) | 1.00 | 1.00 | 1.00 |
| Cuneate nucleus | 1/28 (4) | 0/7 (0) | 0/8 (0) | 1/13 (8) | 1.00 | 1.00 | 1.00 | 2/28 (7) | 0/7 (0) | 0/8 (0) | 2/13 (15) | 1.00 | 0.52 | 0.51 |
| Dorsal motor nucleus of the vagus | 3/28 (11) | 1/7 (14) | 0/8 (0) | 2/13 (15) | 0.47 | 1.00 | 0.51 | 3/28 (11) | 1/7 (14) | 1/8 (13) | 1/13 (8) | 1.00 | 1.00 | 1.00 |
| Hypoglossal nucleus | 2/28 (7) | 0/7 (0) | 0/8 (0) | 2/13 (15) | 1.00 | 0.52 | 0.51 | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 |
| Inferior olivary nucleus | 8/28 (29) | 1/7 (14) | 2/8 (25) | 5/13 (38) | 1.00 | 0.35 | 0.66 | 6/28 (21) | 3/7 (43) | 2/8 (25) | 1/13 (8) | 0.61 | 0.10 | 0.53 |
| Lateral reticular formation | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 |
| Nucleus of the spinal trigeminal tract | 2/28 (7) | 0/7 (0) | 2/8 (25) | 0/13 (0) | 0.47 | 1.00 | 0.13 | 1/28 (4) | 1/7 (14) | 0/8 (0) | 0/13 (0) | 0.47 | 0.35 | 1.00 |
| Nucleus of the solitary tract | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 | 2/28 (7) | 1/7 (14) | 1/8 (13) | 0/13 (0) | 1.00 | 0.35 | 0.38 |
| Vestibular nucleus | 1/28 (4) | 0/7 (0) | 0/8 (0) | 1/13 (8) | 1.00 | 1.00 | 1.00 | 4/28 (14) | 0/7 (0) | 1/8 (13) | 3/13 (23) | 1.00 | 0.52 | 1.00 |
| Other | ||||||||||||||
| Amygdala | 7/26 (27) | 2/6 (33) | 2/7 (29) | 3/13 (23) | 1.00 | 1.00 | 1.00 | 7/27 (26) | 1/7 (14) | 2/7 (29) | 4/13 (31) | 1.00 | 0.61 | 1.00 |
| Lateral geniculate nucleus | 8/26 (31) | 1/6 (17) | 1/7 (14) | 6/13 (46) | 1.00 | 0.33 | 0.33 | 0/28 (0) | 0/7 (0) | 0/8 (0) | 0/13 (0) | 1.00 | 1.00 | 1.00 |
Bold indicates significance, which was taken at p < 0.05. Italics indicates a trend, which was taken at p = 0.05–0.1.