Fig. 2.

Nutraceuticals as therapeutics for PD, able to limit ER stress and protein misfolding and aggregation. The formation of misfolded proteins triggers the onset of ER stress, whose progression leads to the aggregation of proteins and eventually autophagy (Green and Levine, 2014). The main target of nutraceuticals as pharmacological treatment aims at clear misfolded proteins and reduce neurodegeneration.