Table 1.

Average % Difference in Mean GRS

Sample Size	Average % Difference in GRS (CI 95%) Significant Iterations	Average % Difference in GRS (CI 95%) All Iterations	% Difference Range (Min – Max)
200	130.87 (120.89 – 140.85)	51.55 (49.01 – 54.10)	0.079 – 198.76
400	108.47 (99.10 – 117.85)	36.60 (34.77 – 38.42)	0.045 – 179.82
600	91.31 (85.58 – 97.05)	29.14 (27.67 – 30.61)	0.024 – 146.82
1000	71.15 (66.91 – 75.39)	22.64 (21.52 – 23.77)	0.006 – 103.84
2000	48.03 (45.66 – 50.40)	16.67 (15.86 – 17.48)	0.006 – 86.71
3000	39.00 (37.45 – 40.56)	13.91 (13.25 – 14.56)	0.001 – 56.55
4000	35.02 (33.20 – 36.84)	11.22 (10.69 – 11.75)	0.016 – 53.26
5000	29.87 (28.43 – 31.31)	10.58 (10.09 – 11.07)	0.014 – 47.12

The average percent difference between trial arms and related confidence intervals are shown for each sample size for both significant iterations and total iterations. Significant iterations were determined by Z-score cut-off scores of ± 1.96 (p < 0.05). Minimum and maximum percent differences found between arms for all 1000 iterations are also shown.