Table 2.

Average % Difference in Variant Dosage

Sample Size	Average % Difference in GRS (CI 95%) Significant Iterations	Average % Difference in GRS (CI 95%) All Iterations	% Difference Range (Min – Max)
200	41.60 (40.57 – 42.62)	51.55 (49.01 – 54.10)	0.079 – 198.76
400	33.80 (32.68 – 34.93)	36.60 (34.77 – 38.42)	0.045 – 179.82
600	91.31 (85.58 – 97.05)	29.14 (27.67 – 30.61)	0.024 – 146.82
1000	71.15 (66.91 – 75.39)	22.64 (21.52 – 23.77)	0.006 – 103.84
2000	48.03 (45.66 – 50.40)	16.67 (15.86 – 17.48)	0.006 – 86.71
3000	39.00 (37.45 – 40.56)	13.91 (13.25 – 14.56)	0.001 – 56.55
4000	35.02 (33.20 – 36.84)	11.22 (10.69 – 11.75)	0.016 – 53.26
5000	29.87 (28.43 – 31.31)	10.58 (10.09 – 11.07)	0.014 – 47.12

The average percent difference in allele dosage for each of the 47 variants used in this study between trial arms and related confidence intervals are shown for each sample size for both significant and total iteration. Significant iterations were determined by Z-score cut-off scores of ± 1.96 (p < 0.05). Minimum and maximum percent differences found between arms are also shown.