Table 2.

Untransformed means and interquartile ranges (IQR) for all cytokines (in pg/mL) for both groups, and correlations between concentrations and clinical severity in the RTT group.

Analyte	LLOD (pg/mL)	Control		Rett		Group diff. p-value	Correlation with CSSb	Correlation p-value
		% detect	Median (IQR)	% detect	Median (IQR)
IL-1βa	0.10	100	38.8 (27.6–66.7)	100	142.9 (74.8–479.3)	.002	.815	.001
IL-2	0.03	81	0.42 (0.17–1.39)	94	0.65 (0.25–1.34)	.488	-.197	.598
IL-4	1.00	100	23.1 (20.0–41.2)	100	22.4 (18.7–35.8)	.431	-.190	.598
IL-5	0.06	100	0.38 (0.21–0.94)	100	0.42 (0.22–0.65)	.383	-.073	.868
IL-6a	0.09	100	1.65 (0.91–2.38)	100	3.96 (2.03–10.65)	.006	.817	.001
IL-8a	0.08	100	189.0 (115.6–348.9)	100	671.9 (271.5–3763.8)	.002	.824	.001
IL-10a	0.10	94	0.69 (0.41–1.14)	100	1.58 (0.96–3.06)	.051	.788	.001
IL-12p70a	0.24	63	0.48 (0.12–6.69)	81	1.31 (0.24–4.37)	.765	-.214	.598
GM-CSF	0.30	100	0.79 (0.56–1.33)	100	2.05 (0.24–4.37)	.004	.725	.004
IFN-γa	0.10	50	0.36 (0.05–1.42)	56	0.34 (0.05–1.36)	.983	.044	.875
TNF-αa	0.10	100	7.72 (4.93–10.44)	100	11.01 (6.57–24.25)	.051	.781	.001
VEGFa	0.10	100	209.4 (156.8–346.0)	100	533.3 (356.9–710.1)	.006	.512	.087

Note: LLOD: Lower limit of detection for each assay.

^aDenotes variable was log-transformed for all statistical analyses.

^bCSS: Clinical severity score. Correlations between concentrations and clinical severity score within RTT only.