Table 3.
Demographic and clinical characteristics of patients with low to deficient PLP concentrations compared to those with normal PLP concentrations.
| Low-to-deficient PLP Group (n = 30) | Normal PLP Group (n = 64) | Statistical test | |
|---|---|---|---|
| Age, years | 58.47 (12.10) | 54.08 (15.67) | t = 1.35, p = 0.18 |
| Sex, No. (%) | |||
| Male | 8 (26.67) | 28 (43.75) | χ2 = 2.52, p = 0.11 |
| Female | 22 (73.33) | 36 (56.25) | |
| BMI | 26.37 (4.21) | 26.95 (5.37) | t = −0.51, p = 0.61 |
| Smokers, No. (%) | 14 (46.67) | 26 (40.63) | χ2 = 0.31, p = 0.58 |
| Education, No. (%) | |||
| Primary | 8 (26.67) | 7 (10.94) | χ2 = 5.09, p = 0.08 |
| Secondary | 17 (56.67) | 36 (56.25) | |
| Tertiary & Quaternary | 5 (16.67) | 21 (32.81) | |
| Bipolar depression, No. (%) | 9 (30.00) | 12 (18.75) | χ2 = 1.49, p = 0.22 |
| Psychotic depression, No. (%) | 8 (26.67) | 13 (20.31) | χ2 = 0.48, p = 0.49 |
| Diabetes, No. (%) | 1 (3.33) | 6 (9.38) | χ2 = 1.08, p = 0.30 |
| Cardiovascular disease, No. (%) | 14 (46.67) | 25 (39) | χ2 = 0.49, p = 0.49 |
| Baseline HAM-D24 | 30.93 (6.42) | 31.05 (6.69) | t = −0.08, p = 0.94 |
| Post-ECT HAM-D24 | 10.10 (7.97) | 10.60 (8.36) | t = −0.28, p = 0.78 |
| Number of ECT sessions | 7.87 (2.19) | 8.02 (2.59) | t = −0.27, p = 0.79 |
| Remitters, No. (%) | 18 (60.00) | 32 (50.00) | χ2 = 0.82, p = 0.37 |
| Medications, No. (%) taking | |||
| SSRI | 9 (30.00) | 13 (20.31) | χ2 = 0.99, p = 0.32 |
| SNRI | 13 (43.33) | 35 (54.69) | χ2 = 1.22, p = 0.27 |
| TCA | 7 (23.33) | 18 (28.13) | χ2 = 0.28, p = 0.59 |
| MAOI | 4 (13.33) | 6 (9.38) | χ2 = 0.31, p = 0.58 |
| Mirtazapine | 8 (26.67) | 24 (37.5) | χ2 = 1.18, p = 0.28 |
| Bupropion | 0 (0.00) | 1 (1.56) | χ2 = 0.48, p = 0.49 |
| Lithium | 8 (26.67) | 26 (40.63) | χ2 = 1.87, p = 0.17 |
| Sodium Valproate/Lamotrigine | 2 (6.67) | 4 (6.25) | χ2 = 0.003, p = 0.95 |
| Antipsychotics | 25 (83.33) | 40 (62.50) | χ2 = 3.80, p = 0.05 |
| Benzodiazepines | 17 (56.67) | 32 (50.00) | χ2 = 0.28, p = 0.60 |
| Non-benzodiazepine hypnotics | 19 (63.33) | 37 (57.81) | χ2 = 0.18, p = 0.67 |
| Pregabalin | 2 (6.67) | 3 (4.69) | χ2 = 0.15, p = 0.70 |
| Other | 5 (16.67) | 11 (17.19) | χ2 = 0.009, p = 0.92 |
| NSAIDs | 8 (26.67) | 14 (21.88) | χ2 = 0.26, p = 0.61 |
| HAMD-24 Item 5, No. (%) | χ2 = 1.35, p = 0.51 | ||
| <1 lb weight loss in week | 20 (66.67) | 48 (75) | |
| >1 lb weight loss in week | 5 (16.67) | 8 (12.5) | |
| >2 lb weight loss in week | 5 (16.67) | 6 (9.38) | |
| Family history depressiona | |||
| Yes, No. (%) | 18 (60.00) | 22 (34.40) | χ2 = 5.49, p = 0.02 |
Data are presented as means with standard deviations (SD) or number (%) per group where appropriate.
Abbreviations: BMI, body mass index; ECT, electroconvulsive therapy; HAM-D24, Hamilton depression rating scale, 24-item version; MAOI, monoamine oxidase inhibitor; SNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.
a
First or second degree relative.