Table 1.
Psychiatric disorders and symptoms associated with autoantibodies in adults.
| DISORDERS/SYMTPOMS | ABS ASSCOCIATED | REFERENCES |
|---|---|---|
| PSYCHIATRIC DISORDERS | ||
| A. CSF | ||
| Psychosis | CV2/CRMP5, HuD, NMDAR,VGKC, Yo | Endres et al., 2015, Endres et al., 2020b |
| B. Serum | ||
| First Episode Psychosis, Psychosis, Post partum Psychosis, induced Psychosis, Schizophrenia | α7nAChR, AMPAR, ANA, APL, CASPR2, CLβ2GPI, CV2, dsDNA, GABAAR, GAD65, HuD, LGI1, Ma1/2, MOG, NMDAR, Recoverin, P (2 B, 2, 5), RNP, sm, SOX1,SSA/,SSB, P (2 B, 2, 5), RNP, sm, SOX1,SSA/,SSB, Synapsin, TPO, TG,VGKC, Yo, Zic4 | Ando et al., 2016; Barbero et al., 2019; Chandle et al., 2009; Dahm et al., 2014; Endres et al., 2020b; Grain et al., 2017; Jézéquel et al., 2017b, Lennox et al., 2017; Mantere et al., 2018; Nikolopoulos et al., 2020, Oviedo-Salcedo et al., 2018; Saether et al., 2017, 2019; Steiner et al., 2013; Shiwaku et al., 2020; Tanaka et al., 2003; Tong et al., 2019; Yarlagadda et al., 2008; Zandian et al., 2017; Zandi et al., 2011 |
| Bipolar disorder/Mania | ATPA, AMPAR, CASPR2, GAD65, NMDAR, Ma1, TPO, TG, VGKC | Barbuti et al., 2017; Endres et al., 2020b; Padmos et al., 2004; Schou et al., 2016; Steiner et al., 2013 |
| Depressive disorder | CASPR2, CRHM1, GAD65, HuD, NMDAR, SOX1, Synapsin | Endres et al., 2020b; Saether et al., 2019; Schou et al., 2016, 2018; Steiner et al., 2013; Tanaka et al., 2003 |
| Obsessive-Compulsive disorder | ABGA | Nicholson et al., 2012; Pearlman et al., 2014 |
| ADHD | PC | Haukanes et al., 2015. Mazon-Cabrera et al., 2019 |
| CASPR2, CRMP1/2, 5-HTR, NAFP, GFAP | ||
| Autism spectrum disorder | GAD65, GM | Mazon-Cabrera et al. (2019) |
| Gilles de la Tourette syndrome | ABGA | Martino et al. (2008) |
| Eating disorder | Ghrelin, α-MSH | Fetissov et al., 2005; Terashi et al., 2011 |
| Addiction | Glutamate, GABA | Vetrile et al. (2015) |
| PSYCHIATRIC SYMPTOMS | ||
| A. CSF | ||
| Psychosis as syndrome (see A) | ||
| Sleep dysfunction | IgLON5 | Honorat et al. (2017) |
| B.Serum | ||
| Psychosis as syndrome (see A) | ||
| Mood dysfunction | ANA, AMPAR, APL, CASPR2, CLβ2GPI, dsDNA, GABAAR, GAD65, NMDAR, RNP, sm, SSA/SSB, VGKC | Ando et al., 2016; Samra et al., 2019; Nikolopoulos et al., 2020; Schou et al., 2016, 2018; Somers et al., 2011 |
| Cognitive dysfunction | ARHGAP26, AMPAR, CASPR2, CL, GABAAR, Hu, LGI1, MOG, NMDAR, PRE-GLRA1 | Bartels et al., 2020; Escudero et al., 2017; Kanapathy et al., 2019; Pettingill et al., 2015; Somers et al., 2011 |
| Catatonia | GABAAR, NMDAR | Ando et al. (2016) |
| Anxiety | APL, GABAAR, GAD65, NMDAR, VGKC | Ando et al., 2016; Henningsen and Meinck, 2003; Pettingill et al., 2015; Somers et al., 2011; Sadetski et al., 2018 |
| Orientation, confusion | AMPAR, CASPR2, GABABR, LGI1, NMDAR, VGKC, GABAAR, DR1, lysoganglioside | Escudero et al., 2017; Somers et al., 2011; Pettingill et al., 2015; Cox et al., 2015 |
| Behavioral dysfunction | CASPR2, GAD65, GABAAR, NMDAR | Pettingill et al., 2015; Schou et al., 2018 |
| Sleep dysfunction | IgLON5 | Honorat et al. (2017) |
Abbreviations: ABGA = anti basal ganglia antibodies, ADHD = attention deficit hyperactive disorder, ARHGAP26 = Rho GTPase-activating protein 26, α-MSH = alpha melanocyte-stimulating hormone, AMPAR = α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, ANA = antinuclear antibodies, ATPA = H/K adenosine triphosphate, CASPR2 = contactin-associated protein 2, CL = cardiolipin, β2GPI = β2 glycoprotein, CRHM1 = cholinergic receptor muscarinic 1, CRMP1/2 = collapsing response mediator protein 1/2, CV2/CRMP5 = cronveinten 2/collapsin response mediator protein 5, dsDNA = double strand DNA, DPPX = dipeptidyl-peptidase-like-protein 6, GABAA/BR = Gamma-aminobutyric acid A/B receptor, GAD65 = glutamic acid decarboxylase 65, GM1 = ganglioside-monosialic acid, LGI1 = leucine-rich glioma inactivated 1, MOG = myelin oligodendrocytic glycoprotein, NAFP = human neuron axon filament protein, NMDAR = N-methyl-D-aspartate receptor, PAGE (2, 2 B, E5) = P antigen (2, 2 B, E5), PC = Purkinje cell, PRE-GLRA1 = pre glycine receptor alpha 1, RNP = ribonucleoprotein, sm = smith antibody, SSA/B = Sjögren’s-syndrome-related antigen A/B, VGKC = voltage gated potassium channel, 5-HTR = serotonin receptor.