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. 2021 Jul 2;16:100288. doi: 10.1016/j.bbih.2021.100288

Table 1.

Key future directions and action items.

Future Direction Action Items:
Methodology
  • 1.

    Standardize inflammation data collection, storage, and processing procedures (e.g., time of blood draw, fasted samples, store all samples at the same temperature)

  • 2.

    Increase investigation of measurement properties of immunological variables that are germane to immunopsychiatry designs (e.g., temporal stability, temporal specificity, dimensionality for aggregate measures)

  • 3.

    Leverage knowledge of these measurement characteristics to plan data collection and analysis

  • 4.

    Utilize statistical approaches that isolate theoretically-relevant variance to increase precision of inferences

Phenotyping
  • 1.

    Diversify the level of psychopathological measurement (e.g., diagnostic cases, total scores, subscales, individual symptoms) to identify which level of measurement has the most robust associations with immunology

  • 2.

    Similarly, explore the possibility for specific inflammatory proteins/processes to have differential relationships with psychopathology

Theory Integration
  • 1.

    Increase conceptual and empirical work placing immunological processes in the context of established psychosocial risk frameworks for psychopathology (e.g., rumination, social stress)

  • 2.

    Extend promising integrated etiological models to clinical research to establish maximally-comprehensive treatment plans