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. 2020 Jul 26;7:100110. doi: 10.1016/j.bbih.2020.100110

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Systemic CID injection induces loss of DsRed + oligodendrocytes and a decrease in MBP staining throughout the CNS. Sections of tissues taken 3 days after the final injection of CID (P4–P11) show reduction in the number of oligodendrocytes and myelin throughout the CNS. Corpus callosum (A), cerebellum (B), optic nerve (C), and spinal cord (D) representative sections from MBP-iCP9 transgenic mice subcutaneously injected with vehicle (VEH) or CID (n = 3/group) were labeled with antibodies to MBP (green), DsRed (red), and DAPI (blue). The bottom panel in each image shows the areas indicated with an asterisk in the top panel (Bar = 25 μm). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 1 — Systemic CID injection induces loss of DsRed + oligodendrocytes and a decrease in MBP staining throughout the CNS. Sections of tissues taken 3 days after the final injection of CID (P4–P11) show reduction in the number of oligodendrocytes and myelin throughout the CNS. Corpus callosum (A), cerebellum (B), optic nerve (C), and spinal cord (D) representative sections from MBP-iCP9 transgenic mice subcutaneously injected with vehicle (VEH) or CID (n = 3/group) were labeled with antibodies to MBP (green), DsRed (red), and DAPI (blue). The bottom panel in each image shows the areas indicated with an asterisk in the top panel (Bar = 25 μm). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)