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. 2020 Jul 26;7:100110. doi: 10.1016/j.bbih.2020.100110

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Oligodendrocyte ablation results in a significant decrease in mature oligodendrocytes and a decrease in myelin proteins. A. Representative images of spinal cord sections labeled with antibodies to CC1 (green), DsRed (red), and DAPI (blue) in vehicle (VEH) and CID injected pups. Note that the CID injected animals (n = 2) show a significant decrease in CC1 and DsRed staining as compared to vehicle. B. Schematic of the every other day (EOD) CID injection and tissue collection. C. Quantification of cell numbers indicate a significant decrease in the number of mature CC1+ oligodendrocytes (p-value = 0.0312) and DsRed + cells (p-value = 0.0001) in CID injected, compared to VEH injected animals. CC1+ and DsRed + cells were counted from 6 areas (2 dorsal, 2 ventral, and 2 lateral) of the spinal cord. D. Western blot analysis of spinal cord tissue indicates that the myelin proteins MAG (p-value = 0.007) and MBP (p-value = 0.005) were decreased significantly after CID injection compared to VEH treated animals (CID n = 3 and VEH n = 2) (Bar = 25 μm). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)