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. 2020 Jul 26;7:100110. doi: 10.1016/j.bbih.2020.100110

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Remyelination is reduced in LPC-induced demyelination in CID treated transgenic mice. Vehicle (VEH, n = 3) and CID treated (n = 5) MBP-iCP9 transgenic mice were injected with LPC at 6 weeks (about 4 weeks after the last CID injection) and sacrificed at 8 weeks of age. Sections were stained using Toluidine Blue stain (upper panels) and remyelinated axons were counted in three regions in the dorsal column. There is a significant decrease (p-value = 0.0225) in the number of remyelinated axons indicating decreased recovery in the CID treated mice. Lower panels show the SEM images. Note the lower level of myelinated axons and the presence of foamy macrophages in the CID treated tissue as indicated by the asterisk (Bar = 10 μm).