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. 2020 Jul 26;7:100110. doi: 10.1016/j.bbih.2020.100110

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — CID treated animals have worse histological outcomes in EAE,which is not reflected in the functional outcome. A. Schematic of the CID injection and the timeline for EAE induction. B. Both Vehicle (VEH, n = 8) and CID (n = 9) treated mice were induced with EAE at 11 weeks of age (about 8 weeks after CID injection). There are no significant differences in the severity of the disease as indicated by the mean clinical score (B) or the overall level of lesion load based on Solochrome staining (C). However, the tissue integrity (D) was worse in the CID treated with a greater degree of myelin perturbation and axonal degeneration (Bar = 5 μm).