Table 1.
Demographic and laboratory characteristics of the three groups.
| MDD-r |
TRD |
non-MDD |
P1 | P2 | P3 | P4 | |
|---|---|---|---|---|---|---|---|
| N = 2850 | N = 570 | N = 2850 | |||||
| Sex; Female, n (%) | 1585 (55.61) | 317 (55.61) | 1585 (55.61) | 0.996 | 0.466 | 0.500 | 0.466 |
| Age; (years) (mean ± SD) | 52.89 ± 16.12 | 52.74 ± 15.84 | 52.59 ± 16.11 | 0.781 | 0.419 | 0.241 | 0.419 |
| Marital status | |||||||
| Unmarried, n (%) | 365 (12.81) | 76 (13.33) | 361 (12.67) | 0.668 | 0.219 | 0.437 | 0.194 |
| Married, n (%) | 1447 (50.77) | 290 (50.88) | 1475 (51.75) | 0.734 | 0.475 | 0.221 | 0.351 |
| Widow, n (%) | 72 (2.53) | 14 (2.45) | 63 (2.21) | 0.473 | 0.108 | 0.217 | 0.229 |
| Divorced, n (%) | 213 (7.47) | 48 (8.42) | 153 (5.37) | 0.001 | 0.227 | <0.001 | 0.007 |
| Unknown, n (%) | 753 (26.42) | 142 (24.91) | 798 (28.00) | 0.203 | 0.224 | 0.090 | 0.061 |
| Body mass index, kg/m2 (mean ± SD) | 27.77 ± 5.91 | 27.68 ± 6.04 | 27.80 ± 5.76 | 0.998 | 0.372 | 0.423 | 0.331 |
| Laboratory | |||||||
| WBC, (cells × 109/L) (mean ± SD) | 7.29 ± 2.29 | 7.68 ± 2.55 | 7.02 ± 2.16 | <0.001 | <0.001 | <0.001 | <0.001 |
| Lymphocytes, (cells × 109/L) (mean ± SD) | 2.23 ± 0.74 | 2.29 ± 0.79 | 2.15 ± 0.72 | <0.001 | 0.047 | <0.001 | <0.001 |
| Eosinophils, (cells × 109/L) (mean ± SD) | 0.20 ± 0.15 | 0.20 ± 0.14 | 0.19 ± 0.17 | 0.046 | 0.5 | 0.009 | 0.067 |
| Eosinophils, (%) (mean ± SD) | 2.82 ± 1.89 | 2.79 ± 1.87 | 2.79 ± 2.01 | 1 | 0.363 | 0.281 | 0.5 |
| Eosinophils < 0.5 cells × 109/L, n (%) | 148 (5.19) | 32 (5.61) | 151 (5.30) | 0.917 | 0.344 | 0.429 | 0.382 |
| Basophils (cell/mm3) (mean ± SD) | 0.05 ± 0.04 | 0.05 ± 0.03 | 0.04 ± 0.03 | <0.001 | 0.5 | <0.001 | <0.001 |
| Basophils, (%) (mean ± SD) | 0.66 ± 0.35 | 0.64 ± 0.34 | 0.64 ± 0.35 | 0.078 | 0.101 | 0.016 | 0.5 |
| Platelets, (cells × 109/L) (mean ± SD) | 253.53 ± 73.68 | 260.55 ± 75.93 | 249.31 ± 67.97 | 0.001 | 0.021 | 0.012 | 0.001 |
| MPV (fL) (mean ± SD) | 10.79 ± 1.91 | 10.98 ± 1.56 | 10.79 ± 2.01 | 0.081 | 0.006 | 0.5 | 0.006 |
| Glucose (mg/dL), (mean ± SD) | 102.77 ± 32.24 | 103.98 ± 31.41 | 101.72 ± 28.51 | 0.186 | 0.202 | 0.096 | 0.056 |
| TSH (0.35–4.94 mIU/L) (mean ± SD) | 2.28 ± 2.46 | 2.43 ± 3.93 | 2.18 ± 1.93 | 0.050 | 0.190 | 0.044 | 0.069 |
| C-reactive protein (mg/L) (mean ± SD) | 7.39 ± 15.56 | 8.15 ± 18.58 | 5.82 ± 10.30 | <0.001 | 0.180 | <0.001 | 0.002 |
| ESR (mm/h), (mean ± SD) | 25.21 ± 20.84 | 26.56 ± 21.89 | 24.27 ± 18.78 | 0.025 | 0.087 | 0.037 | 0.010 |
| C3 (g/dL), (mean ± SD) | 133.99 ± 25.60 | 133.95 ± 21.91 | 139.25 ± 24.54 | <0.001 | 0.484 | <0.001 | <0.001 |
| C4 (g/dL), (mean ± SD) | 35.31 ± 9.97 | 37.41 ± 11.19 | 36.38 ± 10.56 | <0.001 | <0.001 | <0.001 | 0.021 |
| Antinuclear antibodies positive (>1:80), n (%) | 98 (3.44) | 33 (5.79) | 61 (2.14) | <0.001 | 0.011 | 0.002 | <0.001 |
| Rheumatoid factor (0–20 IU/ml), (mean ± SD) | 14.94 ± 33.19 | 15.39 ± 13.25 | 14.12 ± 26.21 | 0.445 | 0.294 | 0.104 | 0.107 |
| IgE (U/mL) (mean ± SD) | 171.75 ± 277.25 | 147.71 ± 252.18 | 175.83 ± 342.75 | 0.135 | 0.021 | 0.311 | 0.012 |
MDD-r - Treatment Responsive Depression group, TRD - Treatment Resistant Depression group, non-MDD – Group without MDD, P1 – ANOVA, P2 – χ2 between MDD-r and TRD groups, P3 – χ2 between MDD-r and non-MDD groups, P4 – χ2 between TRD and non-MDD groups.