Table 3.
Summary of ELS and FKBP5 interaction results.
| Measurements | Factors |
|||||
|---|---|---|---|---|---|---|
| Genotype | ELS | Sex | Age | Interactions | Key finding(s) | |
| CORT levels | Yes | Yes | Yes | Yes | Gen x ELS | Young mice are susceptible to high levels of FKBP5 |
| Depressive-like symptoms | Yes | No | No | Yes | None | ELS protects aged effect on rTgFKBP5 mice |
| Fear expression | Yes | No | Yes | Yes | None | Age modestly increases fear expression |
| Neural proliferation and differentiation | Yes (Ki-67) | No | – | Yes (Ki-67) | Gen x ELS (Ki-67) | Aged rTgFKBP5 mice showed increased proliferation. |
| HPC neurons | No | No | – | Yes | None | Age negatively impacts number of neurons in rTgFKBP5 mice |
| Neuroinflammation | Yes (GFAP) | No | – | Yes | Gen x ELS (GFAP, Iba1) | FKBP5 induces microglia expression in aged mice and ELS prevents this effect. |
DCX: doublecortin, GFAP: Glial fibrillary acidic protein, Iba1: Ionized calcium binding adaptor molecule 1, ELS: early life stress, Gen: genotype, CORT: corticosterone, HPC: hippocampus.