Table 4.
Predictive abilities of the immune signatures at birth. Mean and 95% Confidence Interval (95% CI) for AUROC, sensitivity, specificity, positive and negative predictive values and optimal threshold of the different models used to predict the risk of belonging to the high-risk group for each of the five dimensions.
| Emotional symptoms |
Conduct problems |
Hyperactivity/Inattention |
Peer problems |
Prosocial behavior problems |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Performance metrics | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI |
| AUROC | 0.716 | [0.685,0.738] | 0.649 | [0.632,0.667] | 0.717 | [0.694,0.732] | 0.659 | [0.625,0.677] | 0.646 | [0.622,0.672] |
| Sensitivity | 0.701 | [0.533,0.85] | 0.612 | [0.367,0.814] | 0.659 | [0.476,0.802] | 0.589 | [0.38,0.829] | 0.667 | [0.434,0.853] |
| Specificity | 0.660 | [0.495,0.807] | 0.622 | [0.416,0.861] | 0.692 | [0.539,0.852] | 0.673 | [0.422,0.853] | 0.580 | [0.374,0.795] |
| Positive Predictive Value | 0.223 | [0.187,0.285] | 0.221 | [0.193,0.327] | 0.265 | [0.224,0.357] | 0.239 | [0.198,0.319] | 0.219 | [0.188,0.271] |
| Negative Predictive Value | 0.939 | [0.923,0.96] | 0.902 | [0.885,0.928] | 0.923 | [0.905,0.942] | 0.903 | [0.886,0.934] | 0.909 | [0.887,0.938] |
| Optimal threshold | 0.125 | [0.079,0.179] | 0.150 | [0.101,0.229] | 0.155 | [0.107,0.231] | 0.159 | [0.107,0.232] | 0.138 | [0.085,0.2] |