Table 4.
Association between the bipolar index and cytokine levels in the replication cohort. A linear regression was run using the bipolar index as the dependent variable and IL-10, IL-15 and IL-27 as the independent variables. Estimates, standard errors (SE), and p-values are shown. An association was considered to be statistically significant when p-value < 0.05. Significant associations were bolded.
| Variable | Estimate | SE | p-value |
|---|---|---|---|
| Sex (Female) | 2.56 | 4.13 | 0.54 |
| Age (years) | −0.27 | 0.14 | 0.06 |
| BMI (Kg.m-2) | 0.24 | 0.40 | 0.56 |
| Tobacco smoking | 2.99 | 3.88 | 0.44 |
| Antidepressors | 0.30 | 4.89 | 0.95 |
| Benzodiazepine | −0.67 | −0.67 | 0.90 |
| Antipsychotics | 5.01 | 3.93 | 0.21 |
| Lithium | 10.77 | 6.03 | 0.08 |
| Anticonvulsants | 25.91 | 6.48 | <0.001 |
| Other psychotropic drugs | 0.07 | 4.43 | 0.99 |
| Antiinflammatory drugs | 3.21 | 8.26 | 0.70 |
| HDRS-17 | −0.10 | 0.58 | 0.86 |
| IL-10 (pg/ml) | 11.46 | 5.77 | <0.05 |
| IL-15 (pg/ml) | 4.66 | 6.05 | 0.44 |
| IL-27 (pg/ml) | 0.00 | 0.00 | 0.86 |