Table 1.

Comparison of outcomes from current studies and Texas studies.

Our studies					Syapin/Bergeson/Agarwal
Drug/Dose mg/kg, ip	EtOH	BAL	Water	Sacch	EtOH	Water
Doxycycline 20	–	–	–	–	–
Doxycycline 40	↓	–	–	↓↓	–
Doxycycline 60	↓↓↓	↓↓↓	–	↓↓↓	↓ M	↓↓ F
Minocycline 40	---	–	–	–	–	–
Minocycline 60	↓	↓	↓↓	↓↓	↓↓ M, ↓F	↓↓
Minocycline 80	↓↓↓	↓↓↓	↓↓	↓↓↓	↓↓↓	↓↓↓F, ↓↓ M
Tigecycline 30	↓↓↓	↓↓↓	↓ F, --_M	–	--- 20 & 40	--- 20 & 40
Tigecycline 60	↓↓↓	↓↓↓	↓ F, ---M	–	↓	–
Tigecycline 90	↓↓↓	↓↓↓	↓↓↓ F, ---M	–	↓↓↓	–

EtOH: consumption (g/kg) of 20% EtOH in DID test. BAL: BAL at end of Day 4, 4 ​h DID test. Water: consumption of water (ml/g) in DID test. Sacch: consumption of 8.5 ​mM sodium saccharin in DID test. Arrows indicate reduced intake (or BAL) vs animals treated with saline vehicle. ↓↓↓ - P ​< ​0.001 (↓↓ - 0.01; ↓ - 0.05). --- No significant reduction vs saline.

M ​= ​males, F ​= ​females where sex differences were detected.