Fig. 1.

Combination IV daptomycin and aerophages in an experimental model of VAP due to MRSA. A Kaplan–Meier survival analysis for rats with pneumonia due to MRSA treated with either placebo (nebulized placebo and IV placebo, n = 8) or aerophages (~ 10¹⁰ plaque forming units (PFU) of nebulized phage cocktail and IV placebo, n = 10), as reported in a previous study (4). B Kaplan–Meier survival analysis for rats with pneumonia due to MRSA from the current study, treated with either IV daptomycin (6 mg/kg and nebulized placebo, n = 3) or IV daptomycin and aerophages (6 mg/kg daptomycin IV, ~ 2 × 10¹⁰ PFU of nebulized phage cocktail, n = 11). C Bacterial densities in the lungs of animals following euthanasia. D Bacterial densities in the spleen of animals following euthanasia. The dotted line represented the limit of detection. Dapto, daptomycin; CFU, colony forming unit