Fig. 1.

Association of CD19±% with re-dosing interval, number of previous infusions, relapses and radiological activity

CD19+%: CD19+ B-cell population expressed as percentage of total lymphocytes

(a) Association of CD19+% with re-dosing interval and number of previous infusions. CD19+% is strongly correlated with re-dosing interval in all patients. Note that there were no patients with ≥3 infusions who had delayed treatment (b) Association of CD19+% with re-dosing interval and relapses (c) Association of CD19+% with re-dosing interval and radiological activity.

p-values shown in (b) and (c) refer to the association of CD19+% repletion (>1%) with either clinically documented relapse or radiological activity.